DPPA3

DPPA3
Identifikatori
Aliasi	DPPA3
Vanjski ID-jevi	OMIM: 608408 HomoloGene: 138483 GeneCards: DPPA3
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12p13.31 Početak 7,711,433 bp Kraj 7,717,559 bp
Ontologija gena Molekularna funkcija • methylated histone binding Ćelijska komponenta • male pronucleus • citoplazma • jedro • female pronucleus Biološki proces • multicellular organism development • protection of DNA demethylation of female pronucleus • negative regulation of DNA demethylation • regulation of genetic imprinting • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	359787	n/a
Ensembl	ENSG00000187569	n/a
UniProt	Q6W0C5	n/a
RefSeq (mRNK)	NM_199286	n/a
RefSeq (bjelančevina)	NP_954980	n/a
Lokacija (UCSC)	Chr 12: 7.71 – 7.72 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Protein 3 sa razvojnom pluripotencijom je protein koji je kod ljudi kodiran genom DPPA3.

Ovaj gen kodira protein koji kod miševa može funkcionirati kao majčinski faktor u preimplantacijskoj fazi razvoja. Kod njih ovaj gen može imati ulogu u transkripcijskoj represiji, ćelijskoj diobi i održavanju pluripotenosti ćelija. Kod ljudi, srodni bezintronski lokusi nalaze se na hromosomima 14 i X.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 150 aminokiselina, a molekulska težina 17 851 Da..

10		20		30		40		50
MDPSQFNPTY		IPGSPQMLTE		ENSRDDSGAS		QISSETLIKN		LSNLTINASS
ESVSPLSEAL		LRRESVGAAV		LREIEDEWLY		SRRGVRTLLS		VQREKMARLR
YMLLGGVRTH		ERRPTNKEPK		GVKKESRPFK		CPCSFCVSNG		WDPSENARIG
NQDTKPLQP

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

• Nakamura T, Arai Y, Umehara H, et al. (2007). "PGC7/Stella protects against DNA demethylation in early embryogenesis". Nat. Cell Biol. 9 (1): 64–71. doi:10.1038/ncb1519. PMID 17143267. S2CID 1947132.
• Elliman SJ, Wu I, Kemp DM (2006). "Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin". J. Biol. Chem. 281 (1): 16–9. doi:10.1074/jbc.C500415200. PMID 16291741.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bortvin A, Goodheart M, Liao M, Page DC (2004). "Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice". BMC Dev. Biol. 4: 2. doi:10.1186/1471-213X-4-2. PMC 362866. PMID 15018652.
• Clark AT, Rodriguez RT, Bodnar MS, et al. (2004). "Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma". Stem Cells. 22 (2): 169–79. doi:10.1634/stemcells.22-2-169. PMID 14990856. S2CID 38136098.
• Bowles J, Teasdale RP, James K, Koopman P (2004). "Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours". Cytogenet. Genome Res. 101 (3–4): 261–5. doi:10.1159/000074346. PMID 14684992. S2CID 7005986.
• Payer B, Saitou M, Barton SC, et al. (2004). "Stella is a maternal effect gene required for normal early development in mice". Curr. Biol. 13 (23): 2110–7. doi:10.1016/j.cub.2003.11.026. PMID 14654002. S2CID 2010581.
• Sato M, Kimura T, Kurokawa K, et al. (2002). "Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells". Mech. Dev. 113 (1): 91–4. doi:10.1016/S0925-4773(02)00002-3. PMID 11900980. S2CID 12877378.