Glipikan 5
Glipikan-5 je protein koji je kod ljudi kodiran genom GPC5, koji se nalazio na hromosomu 13, sekvenca 13q31.3, raspon baznih parova 91,398.621 – 92,873,682 bp.[5][6]
Heparan sulfatni proteoglikani na površini ćelije, sastoje se od proteinskog jezgra povezanog s membranom, supstituirane s promjenjivim brojem lanaca heparan-sulfata. Članovi glipikano povezane proteoglikanske porodice membrana (GRIPS) sadrže jezgreni protein usidren u citoplazmatsku membranu, preko veze glikozil-fosfatidilinositola. Ovi proteini mogu imati ulogu u kontroli diobe ćelija i regulaciji rasta.[6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 572 aminokiseline, a molekulska težina 63.707 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDAQTWPVGF | RCLLLLALVG | SARSEGVQTC | EEVRKLFQWR | LLGAVRGLPD | ||||
| SPRAGPDLQV | CISKKPTCCT | RKMEERYQIA | ARQDMQQFLQ | TSSSTLKFLI | ||||
| SRNAAAFQET | LETLIKQAEN | YTSILFCSTY | RNMALEAAAS | VQEFFTDVGL | ||||
| YLFGADVNPE | EFVNRFFDSL | FPLVYNHLIN | PGVTDSSLEY | SECIRMARRD | ||||
| VSPFGNIPQR | VMGQMGRSLL | PSRTFLQALN | LGIEVINTTD | YLHFSKECSR | ||||
| ALLKMQYCPH | CQGLALTKPC | MGYCLNVMRG | CLAHMAELNP | HWHAYIRSLE | ||||
| ELSDAMHGTY | DIGHVLLNFH | LLVNDAVLQA | HLNGQKLLEQ | VNRICGRPVR | ||||
| TPTQSPRCSF | DQSKEKHGMK | TTTRNSEETL | ANRRKEFINS | LRLYRSFYGG | ||||
| LADQLCANEL | AAADGLPCWN | GEDIVKSYTQ | RVVGNGIKAQ | SGNPEVKVKG | ||||
| IDPVINQIID | KLKHVVQLLQ | GRSPKPDKWE | LLQLGSGGGM | VEQVSGDCDD | ||||
| EDGCGGSGSG | EVKRTLKITD | WMPDDMNFSD | VKQIHQTDTG | STLDTTGAGC | ||||
| AVATESMTFT | LISVVMLLPG | IW |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Također pogledajte
[uredi | uredi izvor]Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000179399 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022112 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G (Jun 1997). "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family". Genomics. 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915.
- ^ a b "Entrez Gene: GPC5 glypican 5".
- ^ "UniProt, P78333". Pristupljeno 11. 9. 2017.
Dopunska literatura
[uredi | uredi izvor]- De Cat B, David G (2001). "Developmental roles of the glypicans". Semin. Cell Dev. Biol. 12 (2): 117–25. doi:10.1006/scdb.2000.0240. PMID 11292377.
- Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.
- Saunders S, Paine-Saunders S, Lander AD (1997). "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain" (PDF). Dev. Biol. 190 (1): 78–93. doi:10.1006/dbio.1997.8690. PMID 9331333.
- Veugelers M, De Cat B, Delande N, et al. (2002). "A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32". Matrix Biol. 20 (5–6): 375–85. doi:10.1016/S0945-053X(01)00143-3. PMID 11566272.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yu W, Inoue J, Imoto I, et al. (2004). "GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines". J. Hum. Genet. 48 (6): 331–5. doi:10.1007/s10038-003-0026-2. PMID 12721791.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.