NUDT6

NUDT6
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3FXT, 3H95
Identifikatori
Aliasi	NUDT6
Vanjski ID-jevi	OMIM: 606261 MGI: 2387618 HomoloGene: 31425 GeneCards: NUDT6
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	122,922,968 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	37,474,360 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• growth factor activity; • hydrolase activity; • NADH pyrophosphatase activity; • ADP-ribose diphosphatase activity; • NAD binding;
Ćelijska komponenta	• citoplazma; • mitohondrija; • jedro; • ćelijska komponenta;
Biološki proces	• regulation of signaling receptor activity; • GO:0022610 biološki proces; • negative regulation of cell population proliferation; • negative regulation of cell cycle;
	Izvori:Amigo / QuickGO
Ortolozi
	11162
	229228
	ENSG00000170917
	ENSMUSG00000050174
	P53370
	Q8CH40
	NM_198041; NM_007083
	NM_001291044; NM_153561
	NP_009014; NP_932158
	NP_001277973; NP_705789
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Motiv 6 nukleozid-difosfatno vezane polovine X jest protein koji je kod ljudi kodiran genom NUDT6 sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 316 aminokiselina, а molekulska težina 35.679 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRQPLSWGRW	RAMLARTYGP	GPSAGYRWAS	GAQGYVRNPP	VGACDLQGEL
DRFGGISVRL	ARLDALDRLD	AAAFQKGLQA	AVQQWRSEGR	TAVWLHIPIL
QSRFIAPAAS	LGFCFHHAES	DSSTLTLWLR	EGPSRLPGYA	SHQVGVAGAV
FDESTRKILV	VQDRNKLKNM	WKFPGGLSEP	EEDIGDTAVR	EVFEETGIKS
EFRSVLSIRQ	QHTNPGAFGK	SDMYIICRLK	PYSFTINFCQ	EECLRCEWMD
LNDLAKTENT	TPITSRVARL	LLYGYREGFD	KIDLTVEELP	AVYTGLFYKL
YHKELPENYK	TMKGID

Funkcija[uredi | uredi izvor]

FGF2 (MIM 134920) je visoko konzervirani, multifunkcijski faktor rasta koji se vezuje za heparin uključen u razvoj neuroektoderme, angiogenezu i zarastanje rana.

Povišeni nivoi FGF2 povezani su sa proliferacijom ćelija glatkih mišića u aterosklerozi i sa proliferacijom tumora. FGF2 antisensni gen, NUDT6, može regulirati ekspresiju gene FGF2 (preme OMIM-u.)^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170917 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050174 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Murphy PR, Knee RS (Jan 1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene". Mol Endocrinol. 8 (7): 852–9. doi:10.1210/me.8.7.852. PMID 7984147.
^ Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells". J Cell Biochem. 72 (4): 492–506. doi:10.1002/(SICI)1097-4644(19990315)72:4<492::AID-JCB5>3.0.CO;2-H. PMID 10022609.
^ ^a ^b "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6".
^ "UniProt, P53370" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Knee RS, Pitcher SE, Murphy PR (1995). "Basic fibroblast growth factor sense (FGF) and antisense (gfg) RNA transcripts are expressed in unfertilized human oocytes and in differentiated adult tissues". Biochem. Biophys. Res. Commun. 205 (1): 577–83. doi:10.1006/bbrc.1994.2704. PMID 7999082.
Li AW, Too CK, Knee R, et al. (1998). "FGF-2 antisense RNA encodes a nuclear protein with MutT-like antimutator activity". Mol. Cell. Endocrinol. 133 (2): 177–82. doi:10.1016/S0303-7207(97)00148-2. PMID 9406864. S2CID 43782586.
Asa SL, Ramyar L, Murphy PR, et al. (2001). "The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production". Mol. Endocrinol. 15 (4): 589–99. doi:10.1210/me.15.4.589. PMID 11266510.
Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant". Clin. Cancer Res. 8 (1): 246–57. PMID 11801566.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sheng Z, Lewis JA, Chirico WJ (2004). "Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by C-terminal signals". J. Biol. Chem. 279 (38): 40153–60. doi:10.1074/jbc.M400123200. PMID 15247275.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
Pezzatini S, Morbidelli L, Solito R, et al. (2007). "Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis". Bone. 41 (4): 523–34. doi:10.1016/j.bone.2007.06.016. PMID 17681892.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170917 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050174 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7984147-5] Murphy PR, Knee RS (Jan 1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene". Mol Endocrinol. 8 (7): 852–9. doi:10.1210/me.8.7.852. PMID 7984147.

[pmid10022609-6] Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells". J Cell Biochem. 72 (4): 492–506. doi:10.1002/(SICI)1097-4644(19990315)72:4<492::AID-JCB5>3.0.CO;2-H. PMID 10022609.

[entrez-7] "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6".

[UniProt-8] "UniProt, P53370" (jezik: engleski). Pristupljeno 30. 10. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]