PRB1

PRB1
Identifikatori
Aliasi	PRB1
Vanjski ID-jevi	OMIM: 180989 GeneCards: PRB1
Lokacija gena (čovjek) Hrom. Hromosom 12 (čovjek) Bend 12p13.2 Početak 11,351,823 bp Kraj 11,355,591 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • molekularna funkcija Ćelijska komponenta • extracellular region Biološki proces • GO:0022610 biološki proces Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	5542	n/a
Ensembl	ENSG00000251655	n/a
UniProt	P04280	n/a
RefSeq (mRNK)	NM_199354 NM_005039 NM_199353 NM_001367912	n/a
RefSeq (bjelančevina)	NP_005030 NP_001354841	n/a
Lokacija (UCSC)	Chr 12: 11.35 – 11.36 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Bazni pljuvačni prolinom bogati protein 1 je protein koji je kod ljudi kodiran genom PRB1.

Protein kodiran ovim genom je prolinom bogat pljuvačni protein. Ovaj i pet drugih gena koji također kodiraju pljuvačne prolinom bogate proteine (PRP), kao i gen koji kodira suznu žlijezdu PRP, tvore PRP genski klaster u regiji p13 hromosoma 12. Opisane su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 392 aminokiseline, a molekulska težina 38.546 Da.

10		20		30		40		50
MLLILLSVAL		LALSSAQNLN		EDVSQEESPS		LIAGNPQGPS		PQGGNKPQGP
PPPPGKPQGP		PPQGGNKPQG		PPPPGKPQGP		PPQGDKSRSP		RSPPGKPQGP
PPQGGNQPQG		PPPPPGKPQG		PPPQGGNKPQ		GPPPPGKPQG		PPPQGDKSQS
PRSPPGKPQG		PPPQGGNQPQ		GPPPPPGKPQ		GPPPQGGNKP		QGPPPPGKPQ
GPPPQGDKSQ		SPRSPPGKPQ		GPPPQGGNQP		QGPPPPPGKP		QGPPQQGGNR
PQGPPPPGKP		QGPPPQGDKS		RSPQSPPGKP		QGPPPQGGNQ		PQGPPPPPGK
PQGPPPQGGN		KPQGPPPPGK		PQGPPAQGGS		KSQSARAPPG		KPQGPPQQEG
NNPQGPPPPA		GGNPQQPQAP		PAGQPQGPPR		PPQGGRPSRP		PQ

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dopunska literatura

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• Kim HS, Lyons KM, Saitoh E, et al. (1993). "The structure and evolution of the human salivary proline-rich protein gene family". Mamm. Genome. 4 (1): 3–14. doi:10.1007/BF00364656. PMID 8422499. S2CID 24058984.
• Castle AM, Castle JD (1998). "Enhanced Glycosylation and Sulfation of Secretory Proteoglycans Is Coupled to the Expression of a Basic Secretory Protein". Mol. Biol. Cell. 9 (3): 575–83. doi:10.1091/mbc.9.3.575. PMC 25286. PMID 9487127.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases". Eur. J. Biochem. 268 (12): 3423–31. doi:10.1046/j.1432-1327.2001.02241.x. PMID 11422372.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.