PLVAP

PLVAP
Identifikatori
Aliasi	PLVAP, FELS, PV-1, PV1, gp68, protein povezan s veziklom plazmaleme, DIAR10
Vanjski ID-jevi	OMIM: 607647 MGI: 1890497 HomoloGene: 10578 GeneCards: PLVAP
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	17,377,342 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	71,964,396 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • protein homodimerization activity;
Ćelijska komponenta	• citoplazma; • perinuklearno područje citoplazme; • Kaveole; • integral component of membrane; • cell surface; • ćelijska membrana; • Egzosom; • membrana;
Biološki proces	• tumor necrosis factor-mediated signaling pathway; • protein kinase C signaling; • MAPK cascade; • positive regulation of cellular extravasation; • GO:0007571 developmental process;
	Izvori:Amigo / QuickGO
Ortolozi
	83483
	84094
	ENSG00000130300
	ENSMUSG00000034845
	Q9BX97
	Q91VC4
	NM_031310
	NM_032398
	NP_112600
	NP_115774
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein plazmalemske vezikule je protein koji je kod ljudi kodiran genom PLVAP.^[5]^[6]

Tkivna specifičnost

Gen PLVAP eksprimira se u plućima, bubrezima, srcu, aorti, posteljici, mišićima, hipofizi, nadbubrežnim i mliječnim žlijezdama, bešici, limfnim čvorovima, koštanoj srži, dušniku, gastrointestinalnom traktu, jetri i tumorskom endotelu.

Struktura

Ovaj glikoprotein sastoji se od 442 aminokiseline, uključujuči malu N-terminalnu regiju, jedan transmembranski fragment i C-terminalni vanćelijski domen. Vanćelijski domen sadrži četiri N-glikozilacijska mjesta i dva velika super namotana alfa-heliksna domena, što ukazuje na štapičastu strukturu proteina. Veličina proteina je, ovisno o nivou glikozilacije, od 50 do 60 kDa.

Aminokiselinska sekvenca
Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MGLAMEHGGS	YARAGGSSRG	CWYYLRYFFL	FVSLIQFLII	LGLVLFMVYG
NVHVSTESNL	QATERRAEGL	YSQLLGLTAS	QSNLTKELNF	TTRAKDAIMQ
MWLNARRDLD	RINASFRQCQ	GDRVIYTNNQ	RYMAAIILSE	KQCRDQFKDM
NKSCDALLFM	LNQKVKTLEV	EIAKEKTICT	KDKESVLLNK	RVAEEQLVEC
VKTRELQHQE	RQLAKEQLQK	VQALCLPLDK	DKFEMDLRNL	WRDSIIPRSL
DNLGYNLYHP	LGSELASIRR	ACDHMPSLMS	SKVEELARSL	RADIERVARE
NSDLQRQKLE	AQQGLRASQE	AKQKVEKEAQ	AREAKLQAEC	SRQTQLALEE
KAVLRKERDN	LAKELEEKKR	EAEQLRMELA	IRNSALDTCI	KTKSQPMMPV
SRPMGPVPNP	QPIDPASLEE	FKRKILESQR	PPAGIPVAPS	SG

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000130300 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034845 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.
↑ "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

Dopunska literatura

Stan RV, Ghitescu L, Jacobson BS, Palade GE (1999). "Isolation, Cloning, and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein". J. Cell Biol. 145 (6): 1189–98. doi:10.1083/jcb.145.6.1189. PMC 2133139. PMID 10366592.
Hnasko R, McFarland M, Ben-Jonathan N (2003). "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands". J. Endocrinol. 175 (3): 649–61. CiteSeerX 10.1.1.322.5434. doi:10.1677/joe.0.1750649. PMID 12475376.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Stan RV, Tkachenko E, Niesman IR (2005). "PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms". Mol. Biol. Cell. 15 (8): 3615–30. doi:10.1091/mbc.E03-08-0593. PMC 491823. PMID 15155804.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strickland LA, Jubb AM, Hongo JA, et al. (2005). "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)". J. Pathol. 206 (4): 466–75. doi:10.1002/path.1805. PMID 15971170. S2CID 45045679.
Carson-Walter EB, Hampton J, Shue E, et al. (2006). "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis". Clin. Cancer Res. 11 (21): 7643–50. doi:10.1158/1078-0432.CCR-05-1099. PMID 16278383.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130300 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034845 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11401446-5] Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.

[entrez-6] "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

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