Receptor vitamina D

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VDR
PDB 2hb8 EBI.jpg
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1DB1, 1IE8, 1IE9, 1KB2, 1KB4, 1KB6, 1S0Z, 1S19, 1TXI, 1YNW, 2HAM, 2HAR, 2HAS, 2HB7, 2HB8, 3A2I, 3A2J, 3A3Z, 3A40, 3A78, 3AUQ, 3AUR, 3AX8, 3AZ1, 3AZ2, 3AZ3, 3B0T, 3CS4, 3CS6, 3KPZ, 3M7R, 3OGT, 3P8X, 3TKC, 3VHW, 4G2I, 3W0A, 3W0C, 3W0Y, 3WGP, 3WWR, 4ITE, 4ITF, 4PA2, 3X31, 3X36

Identifikatori
AliasiVDR, NR1I1, PPP1R163, receptor vitamina D (1,25- dihidroksivitamin D3), receptor vitamina D
Vanjski ID-jeviOMIM: 601769 MGI: 103076 HomoloGene: 37297 GeneCards: VDR
Lokacija gena (čovjek)
Hromosom 12 (čovjek)
Hrom.Hromosom 12 (čovjek)[1]
Hromosom 12 (čovjek)
Genomska lokacija za VDR
Genomska lokacija za VDR
Bend12q13.11Početak47,841,537 bp[1]
Kraj47,943,048 bp[1]
Lokacija gena (miš)
Hromosom 15 (miš)
Hrom.Hromosom 15 (miš)[2]
Hromosom 15 (miš)
Genomska lokacija za VDR
Genomska lokacija za VDR
Bend15|15 F1Početak97,752,306 bp[2]
Kraj97,808,511 bp[2]
Obrazac RNK ekspresije
PBB GE VDR 204255 s at fs.png

PBB GE VDR 204254 s at fs.png

PBB GE VDR 204253 s at fs.png
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija lithocholic acid binding
sequence-specific DNA binding
DNA binding
lithocholic acid receptor activity
GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity
steroid hormone receptor activity
GO:0001948, GO:0016582 protein binding
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
zinc ion binding
metal ion binding
vitamin D response element binding
retinoid X receptor binding
calcitriol binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000975 transcription cis-regulatory region binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
vitamin D binding
transcription factor binding
nuclear receptor coactivator activity
signaling receptor activity
Ćelijska komponenta Jedro
Nukleoplazma
receptor complex
RNA polymerase II transcription regulator complex
citoplazma
Biološki proces negative regulation of cell population proliferation
positive regulation of apoptotic process involved in mammary gland involution
positive regulation of keratinocyte differentiation
regulation of calcidiol 1-monooxygenase activity
intestinal absorption
calcium ion transport
steroid hormone mediated signaling pathway
GO:0009373 regulation of transcription, DNA-templated
lactation
bile acid signaling pathway
animal organ morphogenesis
GO:0000767 cell morphogenesis
skeletal system development
GO:1901313 positive regulation of gene expression
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
multicellular organism development
negative regulation of keratinocyte proliferation
decidualization
GO:1901227 negative regulation of transcription by RNA polymerase II
GO:0045996 negative regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
positive regulation of vitamin D 24-hydroxylase activity
mammary gland branching involved in pregnancy
GO:0072468 signal transduction
cellular calcium ion homeostasis
transcription, DNA-templated
vitamin D receptor signaling pathway
vitamin D metabolic process
Ćelijska diferencijacija
intracellular receptor signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_000376
NM_001017535
NM_001017536
NM_001364085
NM_001374661

NM_001374662

NM_009504

RefSeq (bjelančevina)
NP_000367
NP_001017535
NP_001017536
NP_001351014
NP_001361590

NP_001361591

NP_033530

Lokacija (UCSC)Chr 12: 47.84 – 47.94 MbChr 15: 97.75 – 97.81 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Receptor kalcitriola – poznat i kao receptor vitamina D (VDR) i NR1 I 1 (potporodica nuklearnih receptora 1, grupa I, član 1) – je član porodice nuklearnih receptora transkripcijskih faktora.[5] Nakon aktivacije vitamina D, VDR formira heterodimer sa retinoidnim X receptorom i veže sa elementima hormonskog odgovora na DNK. To rezultira u ispoljavanju ili transrepresiji specifičnih genskih proizvoda. VDR-i ne reguliraju samo transkripcijski odgovor, već su uključeni i u posttranskripcijske mehanizme koje usmjerava mikroRNK.[6] Kod ljudi, receptor vitamina D je kodiran genom VDR.[7]

Glukokortikoidi su poznati po smanjivanju ekspresije VDR, što se ispoljava u većini tkiva, a u probavnom traktu regulira transport kalcija, željeza i ostalih minerala.[8]

Funkcija[uredi | uredi izvor]

Sinteza receptora vitamina vitamina D3 je genetički kontrolrana. Ovaj receptor istovremeno funkcionira i kao sekundarna žučna i lithoholna kiselina. Receptor pripada porodici of trans-activnih transcripcijskih regulatornih factora i pokazuju sličnost sekvence sa receptorima steroidnih i tiroidnih hormona.[9]

Nizvodni ciljevi ovog nuklearnog receptora hormona su uključeni uglavnom u metabolizam minerala, iako receptor regulira i niz drugih metaboličkih puteva, kao što su oni koji su uključeni u imuni odgovor i rak.[10]

Mutacije u ovom genu su povezane sa rezistentnošću rahitisa na vitamin D, tip II. Jednostruki nuklearni polimorfizam u inicijacijskom kodonu rezultira izmijenjenom translacijom startnog mjesta, tri kodona nizvodno. Alternativna prerada RNK se ispoljava u više transkribiranih varijanti koje kodiraju isti protein.[11]

Receptor vitamina D ima važnu ulogu u reguliranju ciklusa rasta dlake. Gubitak gena VDR je, kod ekperimentalnih životinja, povezan sa gubitkom dlake[12] |slušnog ježaExperimentalna proučavanja pokazuju da neligandirani VDR stupa u interakciju sa ragulacijskom ciljnom regijom gena cWnt (wnt signalni put) i slušnog ježa i pokreće ovaj put tokom postnatalnog ciklusa rasta dlake.[13] Ove studije su otkrile nove akcije neligandskih VDR u reguliranju post-morfogenog ciklusa dlake.

Interakcije[uredi | uredi izvor]

Kalcitriolski receptor pokazuje interakcije protein-proteinrotein-protein sa

Također pogledajte[uredi | uredi izvor]

Reference[uredi | uredi izvor]

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  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022479 - Ensembl, maj 2017
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  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Vanjski linkovi[uredi | uredi izvor]