STX1A

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STX1A
Identifikatori
AliasiSTX1A
Vanjski ID-jeviOMIM: 186590 MGI: 109355 HomoloGene: 37941 GeneCards: STX1A
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za STX1A
Genomska lokacija za STX1A
Bend7q11.23Početak73,699,206 bp[1]
Kraj73,719,672 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za STX1A
Genomska lokacija za STX1A
Bend5|5 G2Početak135,052,336 bp[2]
Kraj135,079,954 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• calcium channel inhibitor activity
• transmembrane transporter binding
• protein N-terminus binding
• SNAP receptor activity
• kinase binding
• chloride channel inhibitor activity
• protein heterodimerization activity
• SNARE binding
• GO:0001948, GO:0016582 vezivanje za proteine
• myosin binding
• protein domain specific binding
• protein-macromolecule adaptor activity
• myosin head/neck binding
• ATP-dependent protein binding
• calcium-dependent protein binding
Ćelijska komponenta• integral component of membrane
• citosol
• membrana
• Sinapsna vezikula
• synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
• voltage-gated potassium channel complex
• ćelijska membrana
• sinapsa
• synaptic vesicle membrane
• secretory granule
• extracellular region
• synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
• međućelijske veze
• SNARE complex
• intracellular organelle
• neuron projection
• synaptobrevin 2-SNAP-25-syntaxin-1a complex
• actomyosin
• GO:0016023 citoplazmatska vezikula
• presynaptic membrane
• GO:0097483, GO:0097481 postsynaptic density
• presynaptic active zone membrane
• Jedarna membrana
• integral component of plasma membrane
• Akson
• GO:0009327 makromolekulani kompleks
• Akrozom
• integral component of synaptic vesicle membrane
• glutamatergic synapse
• integral component of presynaptic membrane
• Endomembranski sistem
• intracellular anatomical structure
Biološki proces• Egzocitoza
• positive regulation of norepinephrine secretion
• synaptic vesicle docking
• secretion by cell
• regulation of insulin secretion
• positive regulation of catecholamine secretion
• positive regulation of neurotransmitter secretion
• positive regulation of calcium ion-dependent exocytosis
• regulation of exocytosis
• response to gravity
• vesicle docking
• positive regulation of excitatory postsynaptic potential
• positive regulation of exocytosis
• intracellular protein transport
• neurotransmitter transport
• vesicle-mediated transport
• calcium-ion regulated exocytosis
• regulation of synaptic vesicle priming
• protein localization to membrane
• modulation of excitatory postsynaptic potential
• synaptic vesicle fusion to presynaptic active zone membrane
• SNARE complex assembly
• cytokine-mediated signaling pathway
• synaptic vesicle exocytosis
• Fuzija vezikula
• GO:0010554 neurotransmitter secretion
• glutamate secretion
• protein sumoylation
• insulin secretion
• regulated exocytosis
• hormone secretion
• synaptic vesicle endocytosis
• membrane fusion
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

6804

20907

Ensembl

ENSG00000106089

ENSMUSG00000007207

UniProt

Q16623
Q75ME0

O35526

RefSeq (mRNK)

NM_001165903
NM_004603

NM_016801
NM_001359179

RefSeq (bjelančevina)

NP_001159375
NP_004594
NP_004594.1

NP_058081
NP_001346108

Lokacija (UCSC)Chr 7: 73.7 – 73.72 MbChr 5: 135.05 – 135.08 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Sintaksin-1A jest protein koji je kod ljudi kodiran genom STX1A sa hromosoma 7.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 288 aminokiselina, a molekulska težina 33.023 Da [6]

1020304050
MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAEN
VEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSI
EQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQ
RQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHS
EIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSD
TKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA

Funkcija[uredi | uredi izvor]

Sinapsne vezikule skladište neurotransmiter koji se oslobađa tokom kalcijem regulisane egzocitoze. Specifičnost oslobađanja neurotransmitera zahteva lokalizaciju sinapsnih vezikula i kalcijskih kanala u aktivnu presinapsnu zonu. Sintaksini funkcionišu u ovom procesu fuzije vezikula.

Sintaksin-1A je član natšprodice sintaksin. Sintaksini su proteini specifični za nervni sistem uključeni u spajanje sinapsnih vezikula sa presinapsnom plazmamembranom. Sintaksini posjeduju jedan C-terminalni transmembranski domen, SNARE (Soluble NSF N-etilmaleimid-sensitive fuzion protein)-Attachment protein Receptor) domen (poznat kao H3), i N-terminalni regulatorni domen (Habc). Sintaksini se vezuju za sinaptotagmin na način ovisan o kalciju i stupaju u interakciju sa naponskim zavisnim kalcijevim i kalijevim kanalima preko C-terminalnog H3 domena. Sintaksin-1A je ključni protein u regulaciji ionskih kanala i sinapsnoj egzocitozi.[7]

Klinički značaj[uredi | uredi izvor]

Sintaksini služe kao supstrat za botulinumski neurotoksin tipa C, metaloproteazu koja blokira egzocitozu i ima visok afinitet za molekulski kompleks koji uključuje alfa-latrotoksinski receptor koji proizvodi eksplozivnu egzocitozu.[8]

Nivo ekspresije STX1A je u direktnoj korelaciji sa inteligencijom u Williamsovom sindromu.[9]

Interaktivna mapa puta[uredi | uredi izvor]

Šablon:NicotineDopaminergicActivity WP1602

Interakcije[uredi | uredi izvor]

Pokazalo se da STX1A reaguje sa:

Također pogledajte[uredi | uredi izvor]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106089 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007207 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bennett MK, Calakos N, Scheller RH (juli 1992). "Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones". Science. 257 (5067): 255–9. Bibcode:1992Sci...257..255B. doi:10.1126/science.1321498. PMID 1321498.
  6. ^ "UniProt, Q16623" (jezik: engleski). Pristupljeno 12. 4. 2022.
  7. ^ "Entrez Gene: STX1A syntaxin 1A (brain)".
  8. ^ Zhang R, Maksymowych AB, Simpson LL (juli 1995). "Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis". Gene. 159 (2): 293–4. doi:10.1016/0378-1119(95)00152-V. PMID 7622072.
  9. ^ Gao MC, Bellugi U, Dai L, Mills DL, Sobel EM, Lange K, Korenberg JR (2010). Toland AE (ured.). "Intelligence in Williams Syndrome is related to STX1A, which encodes a component of the presynaptic SNARE complex". PLOS ONE. 5 (4): e10292. Bibcode:2010PLoSO...510292G. doi:10.1371/journal.pone.0010292. PMC 2858212. PMID 20422020.
  10. ^ a b c d Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (august 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". The EMBO Journal. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
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  16. ^ Hanson PI, Otto H, Barton N, Jahn R (juli 1995). "The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin". The Journal of Biological Chemistry. 270 (28): 16955–61. doi:10.1074/jbc.270.28.16955. PMID 7622514.
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  20. ^ Quick MW (april 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proceedings of the National Academy of Sciences of the United States of America. 99 (8): 5686–91. Bibcode:2002PNAS...99.5686Q. doi:10.1073/pnas.082712899. PMC 122832. PMID 11960023.
  21. ^ Deken SL, Beckman ML, Boos L, Quick MW (oktobar 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nature Neuroscience. 3 (10): 998–1003. doi:10.1038/79939. PMID 11017172. S2CID 11312913.
  22. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (septembar 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  23. ^ a b Hata Y, Südhof TC (juni 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
  24. ^ Gonelle-Gispert C, Molinete M, Halban PA, Sadoul K (septembar 2000). "Membrane localization and biological activity of SNAP-25 cysteine mutants in insulin-secreting cells". Journal of Cell Science. 113 ( Pt 18) (18): 3197–205. doi:10.1242/jcs.113.18.3197. PMID 10954418.
  25. ^ Ilardi JM, Mochida S, Sheng ZH (februar 1999). "Snapin: a SNARE-associated protein implicated in synaptic transmission". Nature Neuroscience. 2 (2): 119–24. doi:10.1038/5673. PMID 10195194. S2CID 25524692.
  26. ^ Li Y, Chin LS, Weigel C, Li L (novembar 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". The Journal of Biological Chemistry. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.
  27. ^ a b Ravichandran V, Chawla A, Roche PA (juni 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
  28. ^ Chapman ER, An S, Barton N, Jahn R (novembar 1994). "SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils". The Journal of Biological Chemistry. 269 (44): 27427–32. doi:10.1016/S0021-9258(18)47003-2. PMID 7961655.
  29. ^ a b Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (decembar 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  30. ^ Imai A, Nashida T, Yoshie S, Shimomura H (august 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
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Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]

Šablon:Proteini vezikulskog transporta Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

Preuzeto iz "https://bs.wikipedia.org/w/index.php?title=STX1A&oldid=3507980"