VPS52
Homolog vakuolskog sortiranjem pridruženog proteina 52 jest protein koji je kod ljudi kodiran genom VPS5VEGF2.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 723 aminokiseline, а molekulska težina 82.221 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAAATMAAA | ARELVLRAGT | SDMEEEEGPL | AGGPGLQEPL | QLGELDITSD | ||||
| EFILDEVDVH | IQANLEDELV | KEALKTGVDL | RHYSKQVELE | LQQIEQKSIR | ||||
| DYIQESENIA | SLHNQITACD | AVLERMEQML | GAFQSDLSSI | SSEIRTLQEQ | ||||
| SGAMNIRLRN | RQAVRGKLGE | LVDGLVVPSA | LVTAILEAPV | TEPRFLEQLQ | ||||
| ELDAKAAAVR | EQEARGTAAC | ADVRGVLDRL | RVKAVTKIRE | FILQKIYSFR | ||||
| KPMTNYQIPQ | TALLKYRFFY | QFLLGNERAT | AKEIRDEYVE | TLSKIYLSYY | ||||
| RSYLGRLMKV | QYEEVAEKDD | LMGVEDTAKK | GFFSKPSLRS | RNTIFTLGTR | ||||
| GSVISPTELE | APILVPHTAQ | RGEQRYPFEA | LFRSQHYALL | DNSCREYLFI | ||||
| CEFFVVSGPA | AHDLFHAVMG | RTLSMTLKHL | DSYLADCYDA | IAVFLCIHIV | ||||
| LRFRNIAAKR | DVPALDRYWE | QVLALLWPRF | ELILEMNVQS | VRSTDPQRLG | ||||
| GLDTRPHYIT | RRYAEFSSAL | VSINQTIPNE | RTMQLLGQLQ | VEVENFVLRV | ||||
| AAEFSSRKEQ | LVFLINNYDM | MLGVLMERAA | DDSKEVESFQ | QLLNARTQEF | ||||
| IEELLSPPFG | GLVAFVKEAE | ALIERGQAER | LRGEEARVTQ | LIRGFGSSWK | ||||
| SSVESLSQDV | MRSFTNFRNG | TSIIQGALTQ | LIQLYHRFHR | VLSQPQLRAL | ||||
| PARAELINIH | HLMVELKKHK | PNF |
Funkcija[uredi | uredi izvor]
Ovaj gen kodira protein sličan supresoru kvaščevog gena za aktinske mutacije 2. Kvašćev protein čini podjedinicu tetramernog Golgijevog asocijativnog retrogradnog proteinskog kompleksa koji je uključen u peromet vezikula) iz ranog i kasnog endosoma, natrag na trans-Golgijevu mrežu. Ovaj gen se nalazi na hromosomu 6 u orijentaciji licem u glavu sa genom koji kodira ribosomni protein S18.[6]
Reference[uredi | uredi izvor]
- ^ a b c ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 GRCh38: Ensembl release 89: ENSG00000236014, ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024319 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Walter L, Gunther E (Dec 1998). "Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex". Genomics. 52 (3): 298–304. doi:10.1006/geno.1998.5463. PMID 9790748.
- ^ a b "Entrez Gene: VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)".
- ^ "UniProt, Q8N1B4" (jezik: engleski). Pristupljeno 5. 10. 2021.
Dopunska literatura[uredi | uredi izvor]
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Stephens R, Horton R, Humphray S, et al. (1999). "Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC". J. Mol. Biol. 291 (4): 789–99. doi:10.1006/jmbi.1999.3004. PMID 10452889.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Liewen H, Meinhold-Heerlein I, Oliveira V, et al. (2005). "Characterization of the human GARP (Golgi associated retrograde protein) complex". Exp. Cell Res. 306 (1): 24–34. doi:10.1016/j.yexcr.2005.01.022. PMID 15878329.