CDIPT

CDIPT
Identifikatori
Aliasi	CDIPT
Vanjski ID-jevi	OMIM: 605893 MGI: 105491 HomoloGene: 7159 GeneCards: CDIPT
Lokacija gena (čovjek) Hrom. Hromosom 16 (čovjek) Bend 16p11.2 Početak 29,858,357 bp Kraj 29,863,414 bp
Lokacija gena (miš) Hrom. Hromosom 7 (miš) Bend 7 F3|7 69.26 cM Početak 126,575,086 bp Kraj 126,579,673 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • phosphotransferase activity, for other substituted phosphate groups • manganese ion binding • alcohol binding • CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity • GO:0001948, GO:0016582 vezivanje za proteine • diacylglycerol binding • carbohydrate binding Ćelijska komponenta • integral component of membrane • Golđijev aparat • endoplasmic reticulum membrane • membrana • Golđijeva membrana • ćelijska membrana • Endoplazmatski retikulum Biološki proces • lipid metabolism • CDP-diacylglycerol metabolic process • phospholipid biosynthetic process • phosphatidylinositol biosynthetic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	10423	52858
Ensembl	ENSG00000103502	ENSMUSG00000030682
UniProt	O14735	Q8VDP6
RefSeq (mRNK)	NM_001286585 NM_001286586 NM_006319 NM_145752	NM_026638 NM_001347656 NM_001379260
RefSeq (bjelančevina)	NP_001273514 NP_001273515 NP_006310 NP_001273514.1 NP_001273515.1 NP_006310.1	NP_001334585 NP_080914 NP_001366189
Lokacija (UCSC)	Chr 16: 29.86 – 29.86 Mb	Chr 7: 126.58 – 126.58 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

CDP–diacilglicerol–inozitol 3–fosfatidiltransferaza jest enzim koji je kod ljudi kodiran genom CDIPT.

Proizvodi razgradnje fosfatidilinozitola su sveprisutni drugi glasnici, koji funkcionišu nizvodno od višestruko vezanih G-proteinskih receptora i tirozin-kinaza koji reguliraju rast ćelija, metabolizam kalcija i aktivnost protein-kinaza C. Dva enzima, CDP-diacilglicerol sintaza i fosfatidilinositol sintaza, uključeni su u biosintezu fosfatidilinozitola. Fosfatidilinozitol sintaza, član porodice CDP-alkohol fosfatidil transferaza klase I, integralni je membranski protein koji se nalazi na citoplazmatskoj strani endoplazmatskog retikuluma i Golgijevog aparata.

Aminokielinska sekvenca

Dužina polipeptidnog lanca je 213 aminokiselina, a molekulska težina 23.539 Da

10		20		30		40		50
MPDENIFLFV		PNLIGYARIV		FAIISFYFMP		CCPLTASSFY		LLSGLLDAFD
GHAARALNQG		TRFGAMLDML		TDRCSTMCLL		VNLALLYPGA		TLFFQISMSL
DVASHWLHLH		SSVVRGSESH		KMIDLSGNPV		LRIYYTSRPA		LFTLCAGNEL
FYCLLYLFHF		SEGPLVGSVG		LFRMGLWVTA		PIALLKSLIS		VIHLITAARN
MAALDAADRA		KKK

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Vanjski linkovi

• Lokacija ljudskog genoma CDIPT i stranica sa detaljima o genu CDIPT u UCSC Genome Browseru.

Dopunska literatura

• Antonsson B (1997). "Phosphatidylinositol synthase from mammalian tissues". Biochim. Biophys. Acta. 1348 (1–2): 179–86. doi:10.1016/s0005-2760(97)00105-7. PMID 9370331.
• Antonsson BE (1994). "Purification and characterization of phosphatidylinositol synthase from human placenta". Biochem. J. 297 (Pt 3): 517–22. doi:10.1042/bj2970517. PMC 1137864. PMID 8110188.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• de Serres FJ, Luisetti M, Ferrarotti I, et al. (2005). "Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles". Monaldi Archives for Chest Disease. 63 (3): 133–41. doi:10.4081/monaldi.2005.630. PMID 16312203.