PRKY

PRKY
Identifikatori
Aliasi	PRKY
Vanjski ID-jevi	OMIM: 400008 GeneCards: PRKY
Lokacija gena (čovjek)
Hrom.	Hromosom Y
Kraj	7,381,548 bp
Ortolozi
	5616
	n/a
	ENSG00000099725
	n/a
	n; a
	n/a
	NM_002760
	n/a
	n/a
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Serin/treonin-protein kinaza PRKY je enzim koji je kod čovjeka kodiran genom PRKY.^[3]^[4] Ovaj gen kodira člana porodice cAMP-ovisnu serin/treonin protein kinazu. Ovaj gen se nalazi na hromozomu Y, blizu granice pseudoautosomne regije. Abnormalna rekombinacija između ovog gena i srodnog gena na hromozomu X čest je uzrok XX muškaraca i XY žene.^[4]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099725 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Klink A, Schiebel K, Winkelmann M, Rao E, Horsthemke B, Ludecke HJ, Claussen U, Scherer G, Rappold G (Sep 1995). "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability". Hum Mol Genet. 4 (5): 869–78. doi:10.1093/hmg/4.5.869. PMID 7633447.
^ ^a ^b "Entrez Gene: PRKY protein kinase, Y-linked".

Dopunska literatura

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jobling MA, Williams GA, Schiebel GA, et al. (1999). "A selective difference between human Y-chromosomal DNA haplotypes". Curr. Biol. 8 (25): 1391–4. doi:10.1016/S0960-9822(98)00020-7. PMID 9889101.
Schiebel K, Winkelmann M, Mertz A, et al. (1998). "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females". Hum. Mol. Genet. 6 (11): 1985–9. doi:10.1093/hmg/6.11.1985. PMID 9302280.
Schiebel K, Mertz A, Winkelmann M, et al. (1997). "FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12→q13". Cytogenet. Cell Genet. 76 (1–2): 49–52. doi:10.1159/000134514. PMID 9154127.
Gläser B, Hierl T, Taylor K, et al. (1997). "High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin". Chromosome Res. 5 (1): 23–30. doi:10.1023/A:1018437301461. PMID 9088640.

Vanjski linkovi

Portal Biologija

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099725 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7633447-3] Klink A, Schiebel K, Winkelmann M, Rao E, Horsthemke B, Ludecke HJ, Claussen U, Scherer G, Rappold G (Sep 1995). "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability". Hum Mol Genet. 4 (5): 869–78. doi:10.1093/hmg/4.5.869. PMID 7633447.

[entrez-4] "Entrez Gene: PRKY protein kinase, Y-linked".

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak