ZNF473
Protein 473 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF473.[5][6]
- Aminokiselinska sekvenca
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAEEFVTLKD | VGMDFTLGDW | EQLGLEQGDT | FWDTALDNCQ | DLFLLDPPRP | ||||
| NLTSHPDGSE | DLEPLAGGSP | EATSPDVTET | KNSPLMEDFF | EEGFSQEIIE | ||||
| MLSKDGFWNS | NFGEACIEDT | WLDSLLGDPE | SLLRSDIATN | GESPTECKSH | ||||
| ELKRGLSPVS | TVSTGEDSMV | HNVSEKTLTP | AKSKEYRGEF | FSYSDHSQQD | ||||
| SVQEGEKPYQ | CSECGKSFSG | SYRLTQHWIT | HTREKPTVHQ | ECEQGFDRNA | ||||
| SLSVYPKTHT | GYKFYVCNEY | GTTFSQSTYL | WHQKTHTGEK | PCKSQDSDHP | ||||
| PSHDTQPGEH | QKTHTDSKSY | NCNECGKAFT | RIFHLTRHQK | IHTRKRYECS | ||||
| KCQATFNLRK | HLIQHQKTHA | AKTTSECQEC | GKIFRHSSLL | IEHQALHAGE | ||||
| EPYKCNERGK | SFRHNSTLKI | HQRVHSGEKP | YKCSECGKAF | HRHTHLNEHR | ||||
| RIHTGYRPHK | CQECVRSFSR | PSHLMRHQAI | HTAEKPYSCA | ECKETFSDNN | ||||
| RLVQHQKMHT | VKTPYECQEC | GERFICGSTL | KCHESVHARE | KQGFFVSGKI | ||||
| LDQNPEQKEK | CFKCNKCEKT | FSCSKYLTQH | ERIHTRGVKP | FECDQCGKAF | ||||
| GQSTRLIHHQ | RIHSRVRLYK | WGEQGKAISS | ASLIKLQSFH | TKEHPFKCNE | ||||
| CGKTFSHSAH | LSKHQLIHAG | ENPFKCSKCD | RVFTQRNYLV | QHERTHARKK | ||||
| PLVCNECGKT | FRQSSCLSKH | QRIHSGEKPY | VCDYCGKAFG | LSAELVRHQR | ||||
| IHTGEKPYVC | QECGKAFTQS | SCLSIHRRVH | TGEKPYRCGE | CGKAFAQKAN | ||||
| LTQHQRIHTG | EKPYSCNVCG | KAFVLSAHLN | QHLRVHTQET | LYQCQRCQKA | ||||
| FRCHSSLSRH | QRVHNKQQYC | L |
Interakcije[uredi | uredi izvor]
Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[6]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142528 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048012 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Dominski Z, Erkmann JA, Yang X, Sanchez R, Marzluff WF (Jan 2002). "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing". Genes Dev. 16 (1): 58–71. doi:10.1101/gad.932302. PMC 155312. PMID 11782445.
- ^ a b "Entrez Gene: ZNF473 zinc finger protein 473".
Dopunska literatura[uredi | uredi izvor]
- Wagner EJ, Marzluff WF (2006). "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase". Mol. Cell. Biol. 26 (17): 6702–12. doi:10.1128/MCB.00391-06. PMC 1592837. PMID 16914750.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Pillai RS, Grimmler M, Meister G, et al. (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing". Genes Dev. 17 (18): 2321–33. doi:10.1101/gad.274403. PMC 196468. PMID 12975319.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.