ZNF649

ZNF649
Identifikatori
Aliasi	ZNF649
Vanjski ID-jevi	OMIM: 611903 HomoloGene: 56964 GeneCards: ZNF649
Lokacija gena (čovjek) Hrom. Hromosom 19 (čovjek) Bend 19q13.41 Početak 51,889,235 bp Kraj 51,905,040 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • vezivanje sa DNK • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje iona metala • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Ćelijska komponenta • intracellular anatomical structure • jedro • Vanćelijsko • nukleoplazma Biološki proces • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	65251	n/a
Ensembl	ENSG00000198093	n/a
UniProt	Q9BS31	n/a
RefSeq (mRNK)	NM_023074	n/a
RefSeq (bjelančevina)	NP_075562	n/a
Lokacija (UCSC)	Chr 19: 51.89 – 51.91 Mb	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

Protein 649 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF649. Nalazi se na hromosomu 19 i ima pet egzona.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MTKAQESLTL		EDVAVDFTWE		EWQFLSPAQK		DLYRDVMLEN		YSNLVSVGYQ
AGKPDALTKL		EQGEPLWTLE		DEIHSPAHPE		IEKADDHLQQ		PLQNQKILKR
TGQRYEHGRT		LKSYLGLTNQ		SRRYNRKEPA		EFNGDGAFLH		DNHEQMPTEI
EFPESRKPIS		TKSQFLKHQQ		THNIEKAHEC		TDCGKAFLKK		SQLTEHKRIH
TGKKPHVCSL		CGKAFYKKYR		LTEHERAHRG		EKPHGCSLCG		KAFYKRYRLT
EHERAHKGEK		PYGCSECGKA		FPRKSELTEH		QRIHTGIKPH		QCSECGRAFS
RKSLLVVHQR		THTGEKPHTC		SECGKGFIQK		GNLNIHQRTH		TGEKPYGCID
CGKAFSQKSC		LVAHQRYHTG		KTPFVCPECG		QPCSQKSGLI		RHQKIHSGEK
PYKCSDCGKA		FLTKTMLIVH		HRTHTGERPY		GCDECEKAYF		YMSCLVKHKR
IHSREKRGDS		VKVENPSTAS		HSLSPSEHVQ		GKSPVNMVTV		AMVAGQCEFA
HILHS

Interakcije

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

Vanjski linkovi

• ZNF649 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)