ZNF649

ZNF649
Identifikatori
Aliasi	ZNF649
Vanjski ID-jevi	OMIM: 611903 HomoloGene: 56964 GeneCards: ZNF649
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	51,905,040 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• intracellular anatomical structure; • jedro; • Vanćelijsko; • nukleoplazma;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	65251
	n/a
	ENSG00000198093
	n/a
	Q9BS31
	n/a
	NM_023074
	n/a
	NP_075562
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein 649 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF649. Nalazi se na hromosomu 19 i ima pet egzona.^[3]^[4]

Aminokiselinska sekvenca: Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MTKAQESLTL	EDVAVDFTWE	EWQFLSPAQK	DLYRDVMLEN	YSNLVSVGYQ
AGKPDALTKL	EQGEPLWTLE	DEIHSPAHPE	IEKADDHLQQ	PLQNQKILKR
TGQRYEHGRT	LKSYLGLTNQ	SRRYNRKEPA	EFNGDGAFLH	DNHEQMPTEI
EFPESRKPIS	TKSQFLKHQQ	THNIEKAHEC	TDCGKAFLKK	SQLTEHKRIH
TGKKPHVCSL	CGKAFYKKYR	LTEHERAHRG	EKPHGCSLCG	KAFYKRYRLT
EHERAHKGEK	PYGCSECGKA	FPRKSELTEH	QRIHTGIKPH	QCSECGRAFS
RKSLLVVHQR	THTGEKPHTC	SECGKGFIQK	GNLNIHQRTH	TGEKPYGCID
CGKAFSQKSC	LVAHQRYHTG	KTPFVCPECG	QPCSQKSGLI	RHQKIHSGEK
PYKCSDCGKA	FLTKTMLIVH	HRTHTGERPY	GCDECEKAYF	YMSCLVKHKR
IHSREKRGDS	VKVENPSTAS	HSLSPSEHVQ	GKSPVNMVTV	AMVAGQCEFA
HILHS

Interakcije[uredi | uredi izvor]

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.^[4]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198093 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang H, Yuan W, Wang Y, Zhu C, Liu B, Wang Y, Yang D, Li Y, Wang C, Wu X, Liu M (Jul 2005). "ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor". Biochem Biophys Res Commun. 333 (1): 206–15. doi:10.1016/j.bbrc.2005.05.101. PMID 15950191.
^ ^a ^b "Entrez Gene: ZNF649 zinc finger protein 649".

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

Vanjski linkovi[uredi | uredi izvor]

ZNF649 protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198093 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15950191-3] Yang H, Yuan W, Wang Y, Zhu C, Liu B, Wang Y, Yang D, Li Y, Wang C, Wu X, Liu M (Jul 2005). "ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor". Biochem Biophys Res Commun. 333 (1): 206–15. doi:10.1016/j.bbrc.2005.05.101. PMID 15950191.

[entrez-4] "Entrez Gene: ZNF649 zinc finger protein 649".

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