EMILIN1

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EMILIN1
Protein EMILIN1 PDB 2KA3.png
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2KA3, 2OII

Identifikatori
AliasiEMILIN1
Vanjski ID-jeviOMIM: 130660 MGI: 1926189 HomoloGene: 5117 GeneCards: EMILIN1
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za EMILIN1
Genomska lokacija za EMILIN1
Bend2p23.3Početak27,078,615 bp[1]
Kraj27,086,403 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za EMILIN1
Genomska lokacija za EMILIN1
Bend5|5 B1Početak30,913,402 bp[2]
Kraj30,921,277 bp[2]
Obrazac RNK ekspresije
PBB GE EMILIN1 204163 at fs.png
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948 protein binding
extracellular matrix constituent conferring elasticity
identical protein binding
integrin binding involved in cell-matrix adhesion
extracellular matrix structural constituent
Ćelijska komponenta collagen trimer
extracellular region
Egzosom
Vanćelijsko
GO:0005578 Vanćelijski matriks
integrin alpha4-beta1 complex
EMILIN complex
collagen-containing extracellular matrix
Biološki proces cell adhesion
cell-matrix adhesion
cell migration
protein homotrimerization
aortic valve morphogenesis
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell-substrate adhesion
negative regulation of angiogenesis
extracellular matrix organization
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of collagen biosynthetic process
elastic fiber assembly
negative regulation of cell activation
negative regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of ERK1 and ERK2 cascade
positive regulation of extracellular matrix assembly
negative regulation of collagen fibril organization
negative regulation of macrophage migration
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_007046

NM_133918

RefSeq (bjelančevina)

NP_008977

NP_598679

Lokacija (UCSC)Chr 2: 27.08 – 27.09 MbChr 5: 30.91 – 30.92 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Interfejser-1 elastinskih mikrofibrila (EMILIN-1) je protein koji je kod ljudi kodiran sa genskog lokusa EMILIN1.[5] To je najbolje opisani član porodice EMILIN glikoproteina vanćelijskog matriksa.[6][7]

Također pogledajte[uredi | uredi izvor]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138080 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029163 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EMILIN1 elastin microfibril interfacer 1".
  6. ^ Doliana R; Mongiat M; Bucciotti F; et al. (1999). "EMILIN, a component of the elastic fiber and a new member of the C1q/tumor necrosis factor superfamily of proteins". J. Biol. Chem. 274 (24): 16773–81. doi:10.1074/jbc.274.24.16773. PMID 10358019. Nepoznati parametar |name-list-format= zanemaren (prijedlog zamjene: |name-list-style=) (pomoć)
  7. ^ Doliana R; Canton A; Bucciotti F; et al. (2000). "Structure, chromosomal localization, and promoter analysis of the human elastin microfibril interfase located proteIN (EMILIN) gene". J. Biol. Chem. 275 (2): 785–92. doi:10.1074/jbc.275.2.785. PMID 10625608. Nepoznati parametar |name-list-format= zanemaren (prijedlog zamjene: |name-list-style=) (pomoć)

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]