CGAS

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CGAS
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4LEW, 4KM5, 4O67, 4MKP, 4LEV, 4O68, 4O69

Identifikatori
AliasiCGAS
Vanjski ID-jeviOMIM: 613973 MGI: 2442261 HomoloGene: 51384 GeneCards: CGAS
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za CGAS
Genomska lokacija za CGAS
Bend6q13Početak73,413,515 bp[1]
Kraj73,452,297 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za CGAS
Genomska lokacija za CGAS
Bend9|9 E1Početak78,337,808 bp[2]
Kraj78,350,519 bp[2]
Ontologija gena
Molekularna funkcija• nucleotidyltransferase activity
• nucleotide binding
• vezivanje iona metala
• GTP binding
• aktivnost sa transferazom
• ATP binding
• vezivanje sa DNK
• 2',3'-cyclic GMP-AMP synthase activity
• double-stranded DNA binding
• chromatin binding
• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta• citoplazma
• citosol
Biološki proces• immune system process
• cyclic nucleotide biosynthetic process
• cellular response to exogenous dsRNA
• Urođeni imunski sistem
• activation of innate immune response
• defense response to virus
• positive regulation of defense response to virus by host
• cellular response to DNA damage stimulus
• positive regulation of type I interferon production
• paracrine signaling
• positive regulation of cellular senescence
• positive regulation of cGMP-mediated signaling
• positive regulation of cAMP-mediated signaling
• regulation of immunoglobulin production
• determination of adult lifespan
• regulation of type I interferon production
• regulation of immune response
• regulation of T cell activation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

115004

214763

Ensembl

ENSG00000164430

ENSMUSG00000032344

UniProt

Q8N884

Q8C6L5

RefSeq (mRNK)

NM_138441

NM_173386

RefSeq (bjelančevina)

NP_612450

NP_775562

Lokacija (UCSC)Chr 6: 73.41 – 73.45 MbChr 9: 78.34 – 78.35 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Cikllična GMP-AMP sintaza jest protein koji je kod ljudi kodiran genom CGAS.[5] To je enzim, nukleotidiltransferaza, cGMP-cAMP sintaza.

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 522 aminokiseline, а molekulska težina 58.814 Da.[6]

1020304050
MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGK
FGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAP
GAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSA
PILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCD
SAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYF
VKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRK
QLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENK
EEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNP
QDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRS
KEFLTKQIEYERNNEFPVFDEF

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164430 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032344 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Pristupljeno 12. 9. 2020.
  6. ^ "UniProt, Q8N884" (jezik: engleski). Pristupljeno 8. 10. 2021.

Vanjski linkovi[uredi | uredi izvor]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Cyclic GMP-AMP synthase (MB21D1)
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