PEA15

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PEA15
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4IZ5, 4IZA, 1N3K,%%s1N3K

Identifikatori
AliasiPEA15
Vanjski ID-jeviOMIM: 603434 MGI: 104799 HomoloGene: 7884 GeneCards: PEA15
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za PEA15
Genomska lokacija za PEA15
Bend1q23.2Početak160,205,380 bp[1]
Kraj160,215,376 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za PEA15
Genomska lokacija za PEA15
Bend1 H3|1 79.54 cMPočetak172,024,295 bp[2]
Kraj172,034,371 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0001948, GO:0016582 protein binding
Ćelijska komponenta citoplazma
microtubule associated complex
Jedro
citosol
Biološki proces MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of apoptotic process
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of glucose import
GO:0097285 Apoptoza
GO:0006859 carbohydrate transport
DNA damage checkpoint signaling
response to morphine
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001297576
NM_001297577
NM_001297578
NM_003768

NM_011063
NM_001329869
NM_001329871
NM_008556

RefSeq (bjelančevina)
NP_001284505
NP_001284506
NP_001284507
NP_003759
NP_001284506.1

NP_003759.1

NP_001316798
NP_001316800
NP_035193

Lokacija (UCSC)Chr 1: 160.21 – 160.22 MbChr 1: 172.02 – 172.03 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Astrocitni fosfoprotein PEA-15 jest protein koji je kod ljudi kodiran genom PEA15 sa hromosoma 1.[5][6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 130 aminokiselina, a molekulska težina 15.040 Da.[6]

1020304050
MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLE
SHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLT
RIPSAKKYKDIIRQPSEEEIIKLAPPPKKA

Funkcija[uredi | uredi izvor]

PEA15 je protein koji sadrži domen efektora smrti (DED) koji se pretežno eksprimira u centralnom nervnom sistemu, posebno u astrocitima.[6]

PEA-15 podstiče autofagiju u ćelijama glioma na način ovisan o JNK.[7]

Interakcije[uredi | uredi izvor]

Pokazalo se da je PEA15 u interakciji sa:

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162734 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013698 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (September 1997). "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers". Genomics. 42 (3): 540–2. doi:10.1006/geno.1997.4768. PMID 9205133.
  6. ^ a b c "Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15".
  7. ^ Böck BC, Tagscherer KE, Fassl A, Krämer A, Oehme I, Zentgraf HW, Keith M, Roth W (July 2010). "The PEA-15 protein regulates autophagy via activation of JNK". J. Biol. Chem. 285 (28): 21644–54. doi:10.1074/jbc.M109.096628. PMC 2898427. PMID 20452983. Arhivirano s originala, 7. 12. 2019. Pristupljeno 26. 2. 2022.
  8. ^ a b Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H (October 1999). "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. Neurosci. 19 (19): 8244–51. doi:10.1523/JNEUROSCI.19-19-08244.1999. PMC 6783010. PMID 10493725.
  9. ^ a b Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (August 1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis". Oncogene. 18 (31): 4409–15. doi:10.1038/sj.onc.1202831. PMID 10442631. S2CID 20510429.
  10. ^ Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H (August 2001). "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell. 1 (2): 239–50. doi:10.1016/s1534-5807(01)00035-1. PMID 11702783.
  11. ^ Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (November 2000). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.
  12. ^ Vaidyanathan H, Ramos JW (August 2003). "RSK2 activity is regulated by its interaction with PEA-15". J. Biol. Chem. 278 (34): 32367–72. doi:10.1074/jbc.M303988200. PMID 12796492.

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]