DPYSL5
Dihidropirimidinazi-srodni protein 5 jest enzim koji je kod ljudi kodiran genom DPYSL5 sa hromosoma 2.[5][6][7]
Amiokiselininska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 564 aminokiseline, a molkekulska iežina 61.421 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLANSASVRI | LIKGGKVVND | DCTHEADVYI | ENGIIQQVGR | ELMIPGGAKV | ||||
| IDATGKLVIP | GGIDTSTHFH | QTFMNATCVD | DFYHGTKAAL | VGGTTMIIGH | ||||
| VLPDKETSLV | DAYEKCRGLA | DPKVCCDYAL | HVGITWWAPK | VKAEMETLVR | ||||
| EKGVNSFQMF | MTYKDLYMLR | DSELYQVLHA | CKDIGAIARV | HAENGELVAE | ||||
| GAKEALDLGI | TGPEGIEISR | PEELEAEATH | RVITIANRTH | CPIYLVNVSS | ||||
| ISAGDVIAAA | KMQGKVVLAE | TTTAHATLTG | LHYYHQDWSH | AAAYVTVPPL | ||||
| RLDTNTSTYL | MSLLANDTLN | IVASDHRPFT | TKQKAMGKED | FTKIPHGVSG | ||||
| VQDRMSVIWE | RGVVGGKMDE | NRFVAVTSSN | AAKLLNLYPR | KGRIIPGADA | ||||
| DVVVWDPEAT | KTISASTQVQ | GGDFNLYENM | RCHGVPLVTI | SRGRVVYENG | ||||
| VFMCAEGTGK | FCPLRSFPDT | VYKKLVQREK | TLKVRGVDRT | PYLGDVAVVV | ||||
| HPGKKEMGTP | LADTPTRPVT | RHGGMRDLHE | SSFSLSGSQI | DDHVPKRASA | ||||
| RILAPPGGRS | SGIW |
Funkcija[uredi | uredi izvor]
Vjeruje se da članovi porodice CRMP, kao što je DPYSL5, imaju ulogu u konusu rasta tokom razvoja nervnog sistema (prema OMIM[7])
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000157851 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029168 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S (Oct 2000). "Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain". J Biol Chem. 275 (35): 27291–302. doi:10.1074/jbc.M910126199. PMID 10851247.
- ^ Horiuchi M, El Far O, Betz H (Nov 2000). "Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain". FEBS Lett. 480 (2–3): 283–6. doi:10.1016/S0014-5793(00)01952-9. PMID 11034345. S2CID 42248702.
- ^ a b "Entrez Gene: DPYSL5 dihydropyrimidinase-like 5".
- ^ "UniProt, Q9BPU6" (jezik: engleski). Pristupljeno 12. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Cross SA, Salomao DR, Parisi JE, et al. (2003). "Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG". Ann. Neurol. 54 (1): 38–50. doi:10.1002/ana.10587. PMID 12838519. S2CID 36493404.
- Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
- Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity". Ann. Neurol. 49 (2): 146–54. doi:10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E. PMID 11220734.
- Ricard D, Rogemond V, Charrier E, et al. (2001). "Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes". J. Neurosci. 21 (18): 7203–14. doi:10.1523/JNEUROSCI.21-18-07203.2001. PMC 6763003. PMID 11549731.
- Mitsui N, Inatome R, Takahashi S, et al. (2002). "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling". EMBO J. 21 (13): 3274–85. doi:10.1093/emboj/cdf328. PMC 125392. PMID 12093729.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.