GNPDA1

GNPDA1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1NE7
Identifikatori
Aliasi	GNPDA1
Vanjski ID-jevi	OMIM: 601798 MGI: 1347054 HomoloGene: 38054 GeneCards: GNPDA1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	142,013,041 bp
Lokacija gena (miš)
Hrom.	Hromosom 18 (miš)
Kraj	38,472,056 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • glucosamine-6-phosphate deaminase activity; • vezivanje identičnih proteina;
Ćelijska komponenta	• Egzosom; • citosol; • citoplazma;
Biološki proces	• N-acetylglucosamine metabolic process; • generation of precursor metabolites and energy; • single fertilization; • glucosamine catabolic process; • carbohydrate metabolic process; • N-acetylglucosamine catabolic process; • UDP-N-acetylglucosamine biosynthetic process; • N-acetylneuraminate catabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	10007
	26384
	ENSG00000113552
	ENSMUSG00000052102
	P46926
	O88958
	NM_005471
	NM_011937
	NP_005462
	NP_036067
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Glukozamin-6-fosfat izomeraza 1 jest enzim koji je kod ljudi kodiran genom GNPDA1 sa hromosoma 5.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 289 aminokiselina, а molekulska težina 32.669 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKLIILEHYS	QASEWAAKYI	RNRIIQFNPG	PEKYFTLGLP	TGSTPLGCYK
KLIEYYKNGD	LSFKYVKTFN	MDEYVGLPRD	HPESYHSFMW	NNFFKHIDIH
PENTHILDGN	AVDLQAECDA	FEEKIKAAGG	IELFVGGIGP	DGHIAFNEPG
SSLVSRTRVK	TLAMDTILAN	ARFFDGELTK	VPTMALTVGV	GTVMDAREVM
ILITGAHKAF	ALYKAIEEGV	NHMWTVSAFQ	QHPRTVFVCD	EDATLELKVK
TVKYFKGLML	VHNKLVDPLY	SIKEKETEKS	QSSKKPYSD

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113552 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052102 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shevchenko V, Hogben M, Ekong R, Parrington J, Lai FA (Oct 1998). "The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization". Gene. 216 (1): 31–8. doi:10.1016/S0378-1119(98)00335-7. PMID 9714720.
^ Wolosker H, Kline D, Bian Y, Blackshaw S, Cameron AM, Fralich TJ, Schnaar RL, Snyder SH (Feb 1998). "Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity". FASEB J. 12 (1): 91–9. doi:10.1096/fasebj.12.1.91. PMID 9438414.
^ "Entrez Gene: GNPDA1 glucosamine-6-phosphate deaminase 1".
^ "UniProt, P46926" (jezik: engleski). Pristupljeno 15. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Weidanz JA, Campbell P, DeLucas LJ, et al. (1995). "Glucosamine 6-phosphate deaminase in normal human erythrocytes". Br. J. Haematol. 91 (1): 72–9. doi:10.1111/j.1365-2141.1995.tb05247.x. PMID 7577655. S2CID 31559803.
Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Oliva G, Fontes MR, Garratt RC, et al. (1996). "Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution". Structure. 3 (12): 1323–32. doi:10.1016/S0969-2126(01)00270-2. hdl:11449/64662. PMID 8747459.
Nakamura Y, Miura K, Fujino Y, et al. (2001). "Evolution, structure, and expression of GNPI/Oscillin orthologous genes". Genomics. 68 (2): 179–86. doi:10.1006/geno.2000.6287. PMID 10964516.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang J, Zhang W, Zou D, et al. (2003). "Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin". J. Cell. Biochem. 88 (5): 932–40. doi:10.1002/jcb.10444. PMID 12616532. S2CID 24448482.
Arreola R, Valderrama B, Morante ML, Horjales E (2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study". FEBS Lett. 551 (1–3): 63–70. doi:10.1016/S0014-5793(03)00896-2. PMID 12965206. S2CID 45050024.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Vanjski linkovi[uredi | uredi izvor]

GNPDA1 lokacija ljudskog genoma UCSC Genome Browser.

GNPDA1 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113552 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052102 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9714720-5] Shevchenko V, Hogben M, Ekong R, Parrington J, Lai FA (Oct 1998). "The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization". Gene. 216 (1): 31–8. doi:10.1016/S0378-1119(98)00335-7. PMID 9714720.

[pmid9438414-6] Wolosker H, Kline D, Bian Y, Blackshaw S, Cameron AM, Fralich TJ, Schnaar RL, Snyder SH (Feb 1998). "Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity". FASEB J. 12 (1): 91–9. doi:10.1096/fasebj.12.1.91. PMID 9438414.

[entrez-7] "Entrez Gene: GNPDA1 glucosamine-6-phosphate deaminase 1".

[UniProt-8] "UniProt, P46926" (jezik: engleski). Pristupljeno 15. 10. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak