QPCT

QPCT
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2ZEE, 2ZEF, 2AFU, 2AFM, 2AFX, 4YU9, 2ZEL, 2ZEG, 2ZEM, 4YWY, 2AFZ, 3PBB, 2ZEH, 2AFS, 3SI0, 2ZEP, 3PBE, 2ZEO, 2ZED, 2AFO, 2ZEN, 2AFW
Identifikatori
Aliasi	QPCT
Vanjski ID-jevi	OMIM: 607065 MGI: 1917786 HomoloGene: 8238 GeneCards: QPCT
Lokacija gena (čovjek) Hrom. Hromosom 2 (čovjek) Bend 2p22.2 Početak 37,342,827 bp Kraj 37,373,322 bp
Lokacija gena (miš) Hrom. Hromosom 17 (miš) Bend 17|17 E3 Početak 79,359,335 bp Kraj 79,397,807 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • vezivanje iona cinka • glutaminyl-peptide cyclotransferase activity • acyltransferase activity • vezivanje iona metala Ćelijska komponenta • Egzosom • extracellular region • specific granule lumen • tertiary granule lumen • ficolin-1-rich granule lumen Biološki proces • peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase • neutrophil degranulation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	25797	70536
Ensembl	ENSG00000115828	ENSMUSG00000024084
UniProt	Q16769	Q9CYK2
RefSeq (mRNK)	NM_012413	NM_027455 NM_001316729
RefSeq (bjelančevina)	NP_036545	NP_001303658 NP_081731
Lokacija (UCSC)	Chr 2: 37.34 – 37.37 Mb	Chr 17: 79.36 – 79.4 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Glutaminil-peptid ciklotransferaza jest enzim koji je kod ljudi kodiran genom QPCT sa hromosoma 2.

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 361 aminokiselina, a molekulska težina 40.877 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MAGGRHRRVV		GTLHLLLLVA		ALPWASRGVS		PSASAWPEEK		NYHQPAILNS
SALRQIAEGT		SISEMWQNDL		QPLLIERYPG		SPGSYAARQH		IMQRIQRLQA
DWVLEIDTFL		SQTPYGYRSF		SNIISTLNPT		AKRHLVLACH		YDSKYFSHWN
NRVFVGATDS		AVPCAMMLEL		ARALDKKLLS		LKTVSDSKPD		LSLQLIFFDG
EEAFLHWSPQ		DSLYGSRHLA		AKMASTPHPP		GARGTSQLHG		MDLLVLLDLI
GAPNPTFPNF		FPNSARWFER		LQAIEHELHE		LGLLKDHSLE		GRYFQNYSYG
GVIQDDHIPF		LRRGVPVLHL		IPSPFPEVWH		TMDDNEENLD		ESTIDNLNKI
LQVFVLEYLH		L

Funkcija

Ovaj gen kodira ljudsku hipofiznu glutaminil ciklazu, koja je odgovorna za prisustvo piroglutamil ostataka u mnogim neuroendokrinim peptidima. Aminokiselinska sekvenca ovog enzima je 86% identična onoj goveđe glutaminil-ciklaze.

Dopunska literatura

• Busby WH, Quackenbush GE, Humm J, et al. (1987). "An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes". J. Biol. Chem. 262 (18): 8532–6. doi:10.1016/S0021-9258(18)47446-7. PMID 3597387.
• Bateman RC, Temple JS, Misquitta SA, Booth RE (2001). "Evidence for essential histidines in human pituitary glutaminyl cyclase". Biochemistry. 40 (37): 11246–50. doi:10.1021/bi011177o. PMID 11551224.
• Schilling S, Hoffmann T, Rosche F, et al. (2002). "Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity". Biochemistry. 41 (35): 10849–57. doi:10.1021/bi0260381. PMID 12196024.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Schilling S, Niestroj AJ, Rahfeld JU, et al. (2004). "Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators". J. Biol. Chem. 278 (50): 49773–9. doi:10.1074/jbc.M309077200. PMID 14522962.
• Booth RE, Misquitta SA, Bateman RC (2004). "Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification". Protein Expr. Purif. 32 (1): 141–6. doi:10.1016/S1046-5928(03)00226-2. PMID 14680951.
• Ezura Y, Kajita M, Ishida R, et al. (2005). "Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women". J. Bone Miner. Res. 19 (8): 1296–301. doi:10.1359/JBMR.040324. PMID 15231017. S2CID 8470506.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Huang KF, Liu YL, Cheng WJ, et al. (2005). "Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13117–22. doi:10.1073/pnas.0504184102. PMC 1201592. PMID 16135565.
• Huang QY, Kung AW (2007). "The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population". Journal of Human Genetics. 52 (9): 757–62. doi:10.1007/s10038-007-0178-6. PMID 17687619.