MIB2
E3 ubikvitin-protein ligaza MIB2 jest enzim koji je kod ljudi kodiran genom MIB2 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 1.013 aminokiselina, a molekulska težina 109.939 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGWKPSEARG | QSQSFQASGL | QPRSLKAARR | ATGRPDRSRA | ARPTMDPSAH | ||||
| RSRAAPPNMD | PDPQAGVQVG | MRVVRGVDWK | WGQQDGGEGG | VGTVVELGRH | ||||
| GSPSTPDRTV | VVQWDQGTRT | NYRAGYQGAH | DLLLYDNAQI | GVRHPNIICD | ||||
| CCKKHGLRGM | RWKCRVCLDY | DLCTQCYMHN | KHELAHAFDR | YETAHSRPVT | ||||
| LSPRQGLPRI | PLRGIFQGAK | VVRGPDWEWG | SQDGGEGKPG | RVVDIRGWDV | ||||
| ETGRSVASVT | WADGTTNVYR | VGHKGKVDLK | CVGEAAGGFY | YKDHLPRLGK | ||||
| PAELQRRVSA | DSQPFQHGDK | VKCLLDTDVL | REMQEGHGGW | NPRMAEFIGQ | ||||
| TGTVHRITDR | GDVRVQFNHE | TRWTFHPGAL | TKHHSFWVGD | VVRVIGDLDT | ||||
| VKRLQAGHGE | WTDDMAPALG | RVGKVVKVFG | DGNLRVAVAG | QRWTFSPSCL | ||||
| VAYRPEEDAN | LDVAERAREN | KSSLSVALDK | LRAQKSDPEH | PGRLVVEVAL | ||||
| GNAARALDLL | RRRPEQVDTK | NQGRTALQVA | AYLGQVELIR | LLLQARAGVD | ||||
| LPDDEGNTAL | HYAALGNQPE | ATRVLLSAGC | RADAINSTQS | TALHVAVQRG | ||||
| FLEVVRALCE | RGCDVNLPDA | HSDTPLHSAI | SAGTGASGIV | EVLTEVPNID | ||||
| VTATNSQGFT | LLHHASLKGH | ALAVRKILAR | ARQLVDAKKE | DGFTALHLAA | ||||
| LNNHREVAQI | LIREGRCDVN | VRNRKLQSPL | HLAVQQAHVG | LVPLLVDAGC | ||||
| SVNAEDEEGD | TALHVALQRH | QLLPLVADGA | GGDPGPLQLL | SRLQASGLPG | ||||
| SAELTVGAAV | ACFLALEGAD | VSYTNHRGRS | PLDLAAEGRV | LKALQGCAQR | ||||
| FRERQAGGGA | APGPRQTLGT | PNTVTNLHVG | AAPGPEAAEC | LVCSELALLV | ||||
| LFSPCQHRTV | CEECARRMKK | CIRCQVVVSK | KLRPDGSEVA | SAAPAPGPPR | ||||
| QLVEELQSRY | RQMEERITCP | ICIDSHIRLV | FQCGHGACAP | CGSALSACPI | ||||
| CRQPIRDRIQ | IFV |
Interakcije[uredi | uredi izvor]
Pokazalo se da MIB2 (gen) ima interakcije sa aktinom alfa 1.[8]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (maj 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- ^ "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
- ^ "UniProt, Q96AX9" (jezik: eng.). Pristupljeno 30. 11. 2021.CS1 održavanje: nepoznati jezik (link)
- ^ Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.
Dopunska literatura[uredi | uredi izvor]
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. PMC 1868282. PMID 14507647.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand". J. Biol. Chem. 280 (23): 22335–42. doi:10.1074/jbc.M501631200. PMID 15824097.
- Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma". DNA Cell Biol. 24 (5): 339–44. doi:10.1089/dna.2005.24.339. PMID 15869411.
- Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma". Am. J. Pathol. 166 (6): 1817–26. doi:10.1016/S0002-9440(10)62491-1. PMC 1602431. PMID 15920166.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion". Oncogene. 25 (53): 7059–69. doi:10.1038/sj.onc.1209688. PMID 16715130.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.