PARP14

PARP14
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3GOY, 3Q6Z, 3Q71, 3SE2, 3SMI, 3SMJ, 3VFQ, 4ABK, 4ABL, 4D86, 4F1L, 4F1Q, 4PY4
Identifikatori
Aliasi	PARP14
Vanjski ID-jevi	OMIM: 610028 MGI: 1919489 HomoloGene: 19697 GeneCards: PARP14
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	122,730,840 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	35,691,914 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • glycosyltransferase activity; • vezivanje sa RNK; • GO:0001948, GO:0016582 vezivanje za proteine; • NAD+ binding; • NAD+ ADP-ribosyltransferase activity; • vezivanje enzima; • protein ADP-ribosylase activity;
Ćelijska komponenta	• membrana; • jedro; • citosol; • citoplazma;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • protein poly-ADP-ribosylation; • protein ADP-ribosylation; • negative regulation of gene expression; • positive regulation of tyrosine phosphorylation of STAT protein; • negative regulation of tyrosine phosphorylation of STAT protein; • negative regulation of interferon-gamma-mediated signaling pathway; • positive regulation of interleukin-4-mediated signaling pathway; • immune system process; • Urođeni imunski sistem; • protein mono-ADP-ribosylation;
	Izvori:Amigo / QuickGO
Ortolozi
	54625
	547253
	ENSG00000173193
	ENSMUSG00000034422
	Q460N5; Q8N546
	Q2EMV9
	NM_017554
	NM_001039530
	NP_060024; NP_060024.2
	NP_001034619
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 14 porodice poli(ADP-riboza) polimeraza jest protein/enzim koji je kod ljudi kodiran genom PARP14 sa hromosoma 3.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.801 aminokiselina, а molekulska težina 202.800 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAVPGSFPLL	VEGSWGPDPP	KNLNTKLQMY	FQSPKRSGGG	ECEVRQDPRS
PSRFLVFFYP	EDVRQKVLER	KNHELVWQGK	GTFKLTVQLP	ATPDEIDHVF
EEELLTKESK	TKEDVKEPDV	SEELDTKLPL	DGGLDKMEDI	PEECENISSL
VAFENLKANV	TDIMLILLVE	NISGLSNDDF	QVEIIRDFDV	AVVTFQKHID
TIRFVDDCTK	HHSIKQLQLS	PRLLEVTNTI	RVENLPPGAD	DYSLKLFFEN
PYNGGGRVAN	VEYFPEESSA	LIEFFDRKVL	DTIMATKLDF	NKMPLSVFPY
YASLGTALYG	KEKPLIKLPA	PFEESLDLPL	WKFLQKKNHL	IEEINDEMRR
CHCELTWSQL	SGKVTIRPAA	TLVNEGRPRI	KTWQADTSTT	LSSIRSKYKV
NPIKVDPTMW	DTIKNDVKDD	RILIEFDTLK	EMVILAGKSE	DVQSIEVQVR
ELIESTTQKI	KREEQSLKEK	MIISPGRYFL	LCHSSLLDHL	LTECPEIEIC
YDRVTQHLCL	KGPSADVYKA	KCEIQEKVYT	MAQKNIQVSP	EIFQFLQQVN
WKEFSKCLFI	AQKILALYEL	EGTTVLLTSC	SSEALLEAEK	QMLSALNYKR
IEVENKEVLH	GKKWKGLTHN	LLKKQNSSPN	TVIINELTSE	TTAEVIITGC
VKEVNETYKL	LFNFVEQNMK	IERLVEVKPS	LVIDYLKTEK	KLFWPKIKKV
NVQVSFNPEN	KQKGILLTGS	KTEVLKAVDI	VKQVWDSVCV	KSVHTDKPGA
KQFFQDKARF	YQSEIKRLFG	CYIELQENEV	MKEGGSPAGQ	KCFSRTVLAP
GVVLIVQQGD	LARLPVDVVV	NASNEDLKHY	GGLAAALSKA	AGPELQADCD
QIVKREGRLL	PGNATISKAG	KLPYHHVIHA	VGPRWSGYEA	PRCVYLLRRA
VQLSLCLAEK	YKYRSIAIPA	ISSGVFGFPL	GRCVETIVSA	IKENFQFKKD
GHCLKEIYLV	DVSEKTVEAF	AEAVKTVFKA	TLPDTAAPPG	LPPAAAGPGK
TSWEKGSLVS	PGGLQMLLVK	EGVQNAKTDV	VVNSVPLDLV	LSRGPLSKSL
LEKAGPELQE	ELDTVGQGVA	VSMGTVLKTS	SWNLDCRYVL	HVVAPEWRNG
STSSLKIMED	IIRECMEITE	SLSLKSIAFP	AIGTGNLGFP	KNIFAELIIS
EVFKFSSKNQ	LKTLQEVHFL	LHPSDHENIQ	AFSDEFARRA	NGNLVSDKIP
KAKDTQGFYG	TVSSPDSGVY	EMKIGSIIFQ	VASGDITKEE	ADVIVNSTSN
SFNLKAGVSK	AILECAGQNV	ERECSQQAQQ	RKNDYIITGG	GFLRCKNIIH
VIGGNDVKSS	VSSVLQECEK	KNYSSICLPA	IGTGNAKQHP	DKVAEAIIDA
IEDFVQKGSA	QSVKKVKVVI	FLPQVLDVFY	ANMKKREGTQ	LSSQQSVMSK
LASFLGFSKQ	SPQKKNHLVL	EKKTESATFR	VCGENVTCVE	YAISWLQDLI
EKEQCPYTSE	DECIKDFDEK	EYQELNELQK	KLNINISLDH	KRPLIKVLGI
SRDVMQARDE	IEAMIKRVRL	AKEQESRADC	ISEFIEWQYN	DNNTSHCFNK
MTNLKLEDAR	REKKKTVDVK	INHRHYTVNL	NTYTATDTKG	HSLSVQRLTK
SKVDIPAHWS	DMKQQNFCVV	ELLPSDPEYN	TVASKFNQTC	SHFRIEKIER
IQNPDLWNSY	QAKKKTMDAK	NGQTMNEKQL	FHGTDAGSVP	HVNRNGFNRS
YAGKNAVAYG	KGTYFAVNAN	YSANDTYSRP	DANGRKHVYY	VRVLTGIYTH
GNHSLIVPPS	KNPQNPTDLY	DTVTDNVHHP	SLFVAFYDYQ	AYPEYLITFR
K

Funkcija

Poli(ADP-ribozil)acija je neposredna DNK-ovisna o oštećenju posttranslacijska modifikacija histon a i drugih jedarnih proteina koja doprinosi preživljavanju oštećenih ćelija koje se razmnožavaju. PARP14 pripada natporodici enzima koji izvode ovu modifikaciju (Ame et al., 2004 PubMed 15273990).

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000173193 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034422 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Poly(ADP-ribose) polymerase family member 14". Pristupljeno 2. 3. 2016.
↑ "UniProt, Q460N5" (jezik: engleski). Pristupljeno 8. 11. 2021.

Vanjski linkovi

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

Šablon:Popravka DNK

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173193 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034422 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Poly(ADP-ribose) polymerase family member 14". Pristupljeno 2. 3. 2016.

[UniProt-6] "UniProt, Q460N5" (jezik: engleski). Pristupljeno 8. 11. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak