POLR1B
Podjedinica RPA2 DNK-usmjerene RNK-polimeraze polimeraze I jest enzim koji je kod ljudi kodiran genom POLR1B sa hromosoma 2.[5]
Amiokiselininska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 1.135 aminokiselina, a molekulska težina 128.229 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDPGSRWRNL | PSGPSLKHLT | DPSYGIPREQ | QKAALQELTR | AHVESFNYAV | ||||
| HEGLGLAVQA | IPPFEFAFKD | ERISFTILDA | VISPPTVPKG | TICKEANVYP | ||||
| AECRGRRSTY | RGKLTADINW | AVNGISKGII | KQFLGYVPIM | VKSKLCNLRN | ||||
| LPPQALIEHH | EEAEEMGGYF | IINGIEKVIR | MLIMPRRNFP | IAMIRPKWKT | ||||
| RGPGYTQYGV | SMHCVREEHS | AVNMNLHYLE | NGTVMLNFIY | RKELFFLPLG | ||||
| FALKALVSFS | DYQIFQELIK | GKEDDSFLRN | SVSQMLRIVM | EEGCSTQKQV | ||||
| LNYLGECFRV | KLNVPDWYPN | EQAAEFLFNQ | CICIHLKSNT | EKFYMLCLMT | ||||
| RKLFALAKGE | CMEDNPDSLV | NQEVLTPGQL | FLMFLKEKLE | GWLVSIKIAF | ||||
| DKKAQKTSVS | MNTDNLMRIF | TMGIDLTKPF | EYLFATGNLR | SKTGLGLLQD | ||||
| SGLCVVADKL | NFIRYLSHFR | CVHRGADFAK | MRTTTVRRLL | PESWGFLCPV | ||||
| HTPDGEPCGL | MNHLTAVCEV | VTQFVYTASI | PALLCNLGVT | PIDGAPHRSY | ||||
| SECYPVLLDG | VMVGWVDKDL | APGIADSLRH | FKVLREKRIP | PWMEVVLIPM | ||||
| TGKPSLYPGL | FLFTTPCRLV | RPVQNLALGK | EELIGTMEQI | FMNVAIFEDE | ||||
| VFAGVTTHQE | LFPHSLLSVI | ANFIPFSDHN | QSPRNMYQCQ | MGKQTMGFPL | ||||
| LTYQDRSDNK | LYRLQTPQSP | LVRPSMYDYY | DMDNYPIGTN | AIVAVISYTG | ||||
| YDMEDAMIVN | KASWERGFAH | GSVYKSEFID | LSEKIKQGDS | SLVFGIKPGD | ||||
| PRVLQKLDDD | GLPFIGAKLQ | YGDPYYSYLN | LNTGESFVMY | YKSKENCVVD | ||||
| NIKVCSNDTG | SGKFKCVCIT | MRVPRNPTIG | DKFASRHGQK | GILSRLWPAE | ||||
| DMPFTESGMV | PDILFNPHGF | PSRMTIGMLI | ESMAGKSAAL | HGLCHDATPF | ||||
| IFSEENSALE | YFGEMLKAAG | YNFYGTERLY | SGISGLELEA | DIFIGVVYYQ | ||||
| RLRHMVSDKF | QVRTTGARDR | VTNQPIGGRN | VQGGIRFGEM | ERDALLAHGT | ||||
| SFLLHDRLFN | CSDRSVAHVC | VKCGSLLSPL | LEKPPPSWSA | MRNRKYNCTL | ||||
| CSRSDTIDTV | SVPYVFRYFV | AELAAMNIKV | KLDVV |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125630 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027395 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa".
- ^ "UniProt, Q9H9Y6" (jezik: engleski). Pristupljeno 18. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Seither P, Zatsepina O, Hoffmann M, Grummt I (1997). "Constitutive and strong association of PAF53 with RNA polymerase I." Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723. S2CID 23487728.
- Miller G, Panov KI, Friedrich JK (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
- Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I". Biol. Chem. 382 (8): 1163–70. doi:10.1515/BC.2001.146. PMID 11592397. S2CID 28819190.
- Shiau AK, Barstad D, Radek JT (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. doi:10.1038/nsb787. PMID 11953755. S2CID 452305.
- Egea PF, Mitschler A, Moras D (2002). "Molecular recognition of agonist ligands by RXRs". Mol. Endocrinol. 16 (5): 987–97. doi:10.1210/me.16.5.987. PMID 11981034.
- Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Yamamoto K, Yamamoto M, Hanada K (2004). "Multiple Protein-Protein Interactions by RNA Polymerase I-Associated Factor PAF49 and Role of PAF49 in rRNA Transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
- Philimonenko VV, Zhao J, Iben S (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034. S2CID 6633625.
- Hillier LW, Graves TA, Fulton RS (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Zhang C, Comai L, Johnson DL (2005). "PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC 1190253. PMID 16055704.
- Percipalle P, Fomproix N, Cavellán E (2006). "The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.
- Panova TB, Panov KI, Russell J, Zomerdijk JC (2006). "Casein Kinase 2 Associates with Initiation-Competent RNA Polymerase I and Has Multiple Roles in Ribosomal DNA Transcription". Mol. Cell. Biol. 26 (16): 5957–68. doi:10.1128/MCB.00673-06. PMC 1592790. PMID 16880508.
- Johnson SS, Zhang C, Fromm J (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.