STEAP2

STEAP2
Identifikatori
Aliasi	STEAP2
Vanjski ID-jevi	OMIM: 605094 MGI: 1921301 HomoloGene: 17682 GeneCards: STEAP2
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	90,238,137 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	5,744,578 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• transporter activity; • vezivanje iona metala; • cupric reductase activity; • ferric-chelate reductase (NADPH) activity; • oxidoreductase activity;
Ćelijska komponenta	• integral component of membrane; • integral component of Golgi membrane; • citosol; • endozom; • membrana; • ćelijska membrana; • early endosome; • trans-Golgi network transport vesicle; • endosome membrane; • integral component of plasma membrane;
Biološki proces	• Endocitoza; • iron ion homeostasis; • copper ion import; • ion transport; • response to hormone; • regulated exocytosis; • Golgi to plasma membrane transport; • iron ion import across cell outer membrane;
	Izvori:Amigo / QuickGO
Ortolozi
	261729
	74051
	ENSG00000157214
	ENSMUSG00000015653
	Q8NFT2
	Q8BWB6
NM_001040665; NM_001040666; NM_001244944; NM_001244945; NM_001244946;
	NM_152999
NM_001103156; NM_001103157; NM_001285469; NM_001285470; NM_001285471;
	NM_028734
NP_001035755; NP_001035756; NP_001231873; NP_001231874; NP_001231875;
	NP_694544
NP_001096626; NP_001096627; NP_001272398; NP_001272399; NP_001272400;
	NP_083010
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Metaloreduktaza STEAP2 jest enzim koji je kod ljudi kodiran genom STEAP2.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 490 aminokiselina, а molekulska težina 56.056 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MESISMMGSP	KSLSETFLPN	GINGIKDARK	VTVGVIGSGD	FAKSLTIRLI
RCGYHVVIGS	RNPKFASEFF	PHVVDVTHHE	DALTKTNIIF	VAIHREHYTS
LWDLRHLLVG	KILIDVSNNM	RINQYPESNA	EYLASLFPDS	LIVKGFNVVS
AWALQLGPKD	ASRQVYICSN	NIQARQQVIE	LARQLNFIPI	DLGSLSSARE
IENLPLRLFT	LWRGPVVVAI	SLATFFFLYS	FVRDVIHPYA	RNQQSDFYKI
PIEIVNKTLP	IVAITLLSLV	YLAGLLAAAY	QLYYGTKYRR	FPPWLETWLQ
CRKQLGLLSF	FFAMVHVAYS	LCLPMRRSER	YLFLNMAYQQ	VHANIENSWN
EEEVWRIEMY	ISFGIMSLGL	LSLLAVTSIP	SVSNALNWRE	FSFIQSTLGY
VALLISTFHV	LIYGWKRAFE	EEYYRFYTPP	NFVLALVLPS	IVILGKIILF
LPCISRKLKR	IKKGWEKSQF	LEEGMGGTIP	HVSPERVTVM

Funkcija[uredi | uredi izvor]

Ovaj gen je član porodice STEAP i kodira šestomembranski protein s više prolaza koji se nalazi u Golgijevom kompleksu, plazmamembrani i vezikulskim cjevastim strukturama u citosolu.

Izuzetno sličan protein kod miša ima i feri reduktaznu i fero reduktaznu aktivnost, te stimulira ćelijsku apsorpciju gvožđa i bakra in vitro. Povećana transkripcijska ekspresija ljudskog gena povezana je s progresijom raka prostate. Opisane su alternativne varijante transkripta, koje kodiraju različite izoforme.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157214 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015653 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.
^ Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
^ ^a ^b "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".
^ "UniProt, Q8NFT2" (jezik: engleski). Pristupljeno 29. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.
Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.
Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID 15897894.
Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer". BMC Cancer. 4: 98. doi:10.1186/1471-2407-4-98. PMC 546010. PMID 15623366.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. doi:10.1097/01.lab.0000038554.26102.c6. PMID 12429817.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157214 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015653 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10613842-5] Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (Jan 2000). "Prediction of Gene Function by Genome-Scale Expression Analysis: Prostate Cancer-Associated Genes". Genome Res. 9 (12): 1198–203. doi:10.1101/gr.9.12.1198. PMC 310991. PMID 10613842.

[pmid12095985-6] Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.

[entrez-7] "Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2".

[UniProt-8] "UniProt, Q8NFT2" (jezik: engleski). Pristupljeno 29. 9. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak