TNXB
(Preusmjereno sa Tenascin X)
Tenascin X, znan i kao heksabrahionoliki protein, jest glikoprotein, član porodice tenascina (TN-X), koji je kod ljudi kodiran genom TNXB. Eksprimira se u vezivnom tkivu, uključujući kožu, zglobove i mišiće.[5]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 4.242 aminokiseline, а molekulska težina 458.220 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MMPAQYALTS | SLVLLVLLST | ARAGPFSSRS | NVTLPAPRPP | PQPGGHTVGA | ||||
| GVGSPSSQLY | EHTVEGGEKQ | VVFTHRINLP | PSTGCGCPPG | TEPPVLASEV | ||||
| QALRVRLEIL | EELVKGLKEQ | CTGGCCPASA | QAGTGQTDVR | TLCSLHGVFD | ||||
| LSRCTCSCEP | GWGGPTCSDP | TDAEIPPSSP | PSASGSCPDD | CNDQGRCVRG | ||||
| RCVCFPGYTG | PSCGWPSCPG | DCQGRGRCVQ | GVCVCRAGFS | GPDCSQRSCP | ||||
| RGCSQRGRCE | GGRCVCDPGY | TGDDCGMRSC | PRGCSQRGRC | ENGRCVCNPG | ||||
| YTGEDCGVRS | CPRGCSQRGR | CKDGRCVCDP | GYTGEDCGTR | SCPWDCGEGG | ||||
| RCVDGRCVCW | PGYTGEDCST | RTCPRDCRGR | GRCEDGECIC | DTGYSGDDCG | ||||
| VRSCPGDCNQ | RGRCEDGRCV | CWPGYTGTDC | GSRACPRDCR | GRGRCENGVC | ||||
| VCNAGYSGED | CGVRSCPGDC | RGRGRCESGR | CMCWPGYTGR | DCGTRACPGD | ||||
| CRGRGRCVDG | RCVCNPGFTG | EDCGSRRCPG | DCRGHGLCED | GVCVCDAGYS | ||||
| GEDCSTRSCP | GGCRGRGQCL | DGRCVCEDGY | SGEDCGVRQC | PNDCSQHGVC | ||||
| QDGVCICWEG | YVSEDCSIRT | CPSNCHGRGR | CEEGRCLCDP | GYTGPTCATR | ||||
| MCPADCRGRG | RCVQGVCLCH | VGYGGEDCGQ | EEPPASACPG | GCGPRELCRA | ||||
| GQCVCVEGFR | GPDCAIQTCP | GDCRGRGECH | DGSCVCKDGY | AGEDCGEEVP | ||||
| TIEGMRMHLL | EETTVRTEWT | PAPGPVDAYE | IQFIPTTEGA | SPPFTARVPS | ||||
| SASAYDQRGL | APGQEYQVTV | RALRGTSWGL | PASKTITTMI | DGPQDLRVVA | ||||
| VTPTTLELGW | LRPQAEVDRF | VVSYVSAGNQ | RVRLEVPPEA | DGTLLTDLMP | ||||
| GVEYVVTVTA | ERGRAVSYPA | SVRANTGSSP | LGLLGTTDEP | PPSGPSTTQG | ||||
| AQAPLLQQRP | QELGELRVLG | RDETGRLRVV | WTAQPDTFAY | FQLRMRVPEG | ||||
| PGAHEEVLPG | DVRQALVPPP | PPGTPYELSL | HGVPPGGKPS | DPIIYQGIMD | ||||
| KDEEKPGKSS | GPPRLGELTV | TDRTSDSLLL | RWTVPEGEFD | SFVIQYKDRD | ||||
| GQPQVVPVEG | PQRSAVITSL | DPGRKYKFVL | YGFVGKKRHG | PLVAEAKILP | ||||
| QSDPSPGTPP | HLGNLWVTDP | TPDSLHLSWT | VPEGQFDTFM | VQYRDRDGRP | ||||
| QVVPVEGPER | SFVVSSLDPD | HKYRFTLFGI | ANKKRYGPLT | ADGTTAPERK | ||||
| EEPPRPEFLE | QPLLGELTVT | GVTPDSLRLS | WTVAQGPFDS | FMVQYKDAQG | ||||
| QPQAVPVAGD | ENEVTVPGLD | PDRKYKMNLY | GLRGRQRVGP | ESVVAKTAPQ | ||||
| EDVDETPSPT | ELGTEAPESP | EEPLLGELTV | TGSSPDSLSL | FWTVPQGSFD | ||||
| SFTVQYKDRD | GRPRAVRVGG | KESEVTVGGL | EPGHKYKMHL | YGLHEGQRVG | ||||
| PVSAVGVTAP | QQEETPPATE | SPLEPRLGEL | TVTDVTPNSV | GLSWTVPEGQ | ||||
| FDSFIVQYKD | KDGQPQVVPV | AADQREVTVY | NLEPERKYKM | NMYGLHDGQR | ||||
| MGPLSVVIVT | APLPPAPATE | ASKPPLEPRL | GELTVTDITP | DSVGLSWTVP | ||||
| EGEFDSFVVQ | YKDRDGQPQV | VPVAADQREV | TIPDLEPSRK | YKFLLFGIQD | ||||
| GKRRSPVSVE | AKTVARGDAS | PGAPPRLGEL | WVTDPTPDSL | RLSWTVPEGQ | ||||
| FDSFVVQFKD | KDGPQVVPVE | GHERSVTVTP | LDAGRKYRFL | LYGLLGKKRH | ||||
| GPLTADGTTE | ARSAMDDTGT | KRPPKPRLGE | ELQVTTVTQN | SVGLSWTVPE | ||||
| GQFDSFVVQY | KDRDGQPQVV | PVEGSLREVS | VPGLDPAHRY | KLLLYGLHHG | ||||
| KRVGPISAVA | ITAGREETET | ETTAPTPPAP | EPHLGELTVE | EATSHTLHLS | ||||
| WMVTEGEFDS | FEIQYTDRDG | QLQMVRIGGD | RNDITLSGLE | SDHRYLVTLY | ||||
| GFSDGKHVGP | VHVEALTVPE | EEKPSEPPTA | TPEPPIKPRL | GELTVTDATP | ||||
| DSLSLSWTVP | EGQFDHFLVQ | YRNGDGQPKA | VRVPGHEEGV | TISGLEPDHK | ||||
| YKMNLYGFHG | GQRMGPVSVV | GVTAAEEETP | SPTEPSMEAP | EPAEEPLLGE | ||||
| LTVTGSSPDS | LSLSWTVPQG | RFDSFTVQYK | DRDGRPQVVR | VGGEESEVTV | ||||
| GGLEPGRKYK | MHLYGLHEGR | RVGPVSAVGV | TAPEEESPDA | PLAKLRLGQM | ||||
| TVRDITSDSL | SLSWTVPEGQ | FDHFLVQFKN | GDGQPKAVRV | PGHEDGVTIS | ||||
| GLEPDHKYKM | NLYGFHGGQR | VGPVSAVGLT | APGKDEEMAP | ASTEPPTPEP | ||||
| PIKPRLEELT | VTDATPDSLS | LSWTVPEGQF | DHFLVQYKNG | DGQPKATRVP | ||||
| GHEDRVTISG | LEPDNKYKMN | LYGFHGGQRV | GPVSAIGVTA | AEEETPSPTE | ||||
| PSMEAPEPPE | EPLLGELTVT | GSSPDSLSLS | WTVPQGRFDS | FTVQYKDRDG | ||||
| RPQVVRVGGE | ESEVTVGGLE | PGRKYKMHLY | GLHEGRRVGP | VSTVGVTAPQ | ||||
| EDVDETPSPT | EPGTEAPGPP | EEPLLGELTV | TGSSPDSLSL | SWTVPQGRFD | ||||
| SFTVQYKDRD | GRPQAVRVGG | QESKVTVRGL | EPGRKYKMHL | YGLHEGRRLG | ||||
| PVSAVGVTED | EAETTQAVPT | MTPEPPIKPR | LGELTMTDAT | PDSLSLSWTV | ||||
| PEGQFDHFLV | QYRNGDGQPK | AVRVPGHEDG | VTISGLEPDH | KYKMNLYGFH | ||||
| GGQRVGPISV | IGVTAAEEET | PSPTELSTEA | PEPPEEPLLG | ELTVTGSSPD | ||||
| SLSLSWTIPQ | GHFDSFTVQY | KDRDGRPQVM | RVRGEESEVT | VGGLEPGRKY | ||||
| KMHLYGLHEG | RRVGPVSTVG | VTEDEAETTQ | AVPTTTPEPP | NKPRLGELTV | ||||
| TDATPDSLSL | SWMVPEGQFD | HFLVQYRNGD | GQPKVVRVPG | HEDGVTISGL | ||||
| EPDHKYKMNL | YGFHGGQRVG | PISVIGVTAA | EEETPAPTEP | STEAPEPPEE | ||||
| PLLGELTVTG | SSPDSLSLSW | TIPQGRFDSF | TVQYKDRDGR | PQVVRVRGEE | ||||
| SEVTVGGLEP | GCKYKMHLYG | LHEGQRVGPV | SAVGVTAPKD | EAETTQAVPT | ||||
| MTPEPPIKPR | LGELTVTDAT | PDSLSLSWMV | PEGQFDHFLV | QYRNGDGQPK | ||||
| AVRVPGHEDG | VTISGLEPDH | KYKMNLYGFH | GGQRVGPVSA | IGVTEEETPS | ||||
| PTEPSTEAPE | APEEPLLGEL | TVTGSSPDSL | SLSWTVPQGR | FDSFTVQYKD | ||||
| RDGQPQVVRV | RGEESEVTVG | GLEPGRKYKM | HLYGLHEGQR | VGPVSTVGIT | ||||
| APLPTPLPVE | PRLGELAVAA | VTSDSVGLSW | TVAQGPFDSF | LVQYRDAQGQ | ||||
| PQAVPVSGDL | RAVAVSGLDP | ARKYKFLLFG | LQNGKRHGPV | PVEARTAPDT | ||||
| KPSPRLGELT | VTDATPDSVG | LSWTVPEGEF | DSFVVQYKDK | DGRLQVVPVA | ||||
| ANQREVTVQG | LEPSRKYRFL | LYGLSGRKRL | GPISADSTTA | PLEKELPPHL | ||||
| GELTVAEETS | SSLRLSWTVA | QGPFDSFVVQ | YRDTDGQPRA | VPVAADQRTV | ||||
| TVEDLEPGKK | YKFLLYGLLG | GKRLGPVSAL | GMTAPEEDTP | APELAPEAPE | ||||
| PPEEPRLGVL | TVTDTTPDSM | RLSWSVAQGP | FDSFVVQYED | TNGQPQALLV | ||||
| DGDQSKILIS | GLEPSTPYRF | LLYGLHEGKR | LGPLSAEGTT | GLAPAGQTSE | ||||
| ESRPRLSQLS | VTDVTTSSLR | LNWEAPPGAF | DSFLLRFGVP | SPSTLEPHPR | ||||
| PLLQRELMVP | GTRHSAVLRD | LRSGTLYSLT | LYGLRGPHKA | DSIQGTARTL | ||||
| SPVLESPRDL | QFSEIRETSA | KVNWMPPPSR | ADSFKVSYQL | ADGGEPQSVQ | ||||
| VDGQARTQKL | QGLIPGARYE | VTVVSVRGFE | ESEPLTGFLT | TVPDGPTQLR | ||||
| ALNLTEGFAV | LHWKPPQNPV | DTYDVQVTAP | GAPPLQAETP | GSAVDYPLHD | ||||
| LVLHTNYTAT | VRGLRGPNLT | SPASITFTTG | LEAPRDLEAK | EVTPRTALLT | ||||
| WTEPPVRPAG | YLLSFHTPGG | QNQEILLPGG | ITSHQLLGLF | PSTSYNARLQ | ||||
| AMWGQSLLPP | VSTSFTTGGL | RIPFPRDCGE | EMQNGAGASR | TSTIFLNGNR | ||||
| ERPLNVFCDM | ETDGGGWLVF | QRRMDGQTDF | WRDWEDYAHG | FGNISGEFWL | ||||
| GNEALHSLTQ | AGDYSMRVDL | RAGDEAVFAQ | YDSFHVDSAA | EYYRLHLEGY | ||||
| HGTAGDSMSY | HSGSVFSARD | RDPNSLLISC | AVSYRGAWWY | RNCHYANLNG | ||||
| LYGSTVDHQG | VSWYHWKGFE | FSVPFTEMKL | RPRNFRSPAG | GG |
Gen[uredi | uredi izvor]
Ovaj gen nalazi se u područje glavnog kompleksa histokompatibilnosti (MHC-klasa III) na hromosomu 6. Struktura ovog gena je neobična po tome što se preklapa s genima CREBL1 i CYP21A2 na svom 5' i 3' kraju.[7]
Funkcija[uredi | uredi izvor]
Ovaj gen kodira člana tenascinske porodice glikoproteina vanćelijskog matriksa. Tenascini imaju anti-adhezivno dejstvo, za razliku od fibronektina koji je ljepljiv. Smatra se da ovaj protein funkcionira u sazrijevanju matriksa tokom zacjeljivanja rana.[7]
Klinički značaj[uredi | uredi izvor]
Nedostatak tenascina uzrokuje klasični oblik Ehlers-Danlosovog sindroma, gdje se gustoća kolagena smanjuje, a elastična vlakna fragmentiraju.[8]
Reference[uredi | uredi izvor]
- ^ a b c ENSG00000236221, ENSG00000229353, ENSG00000229341, ENSG00000233323, ENSG00000231608, ENSG00000206258, ENSG00000168477 GRCh38: Ensembl release 89: ENSG00000236236, ENSG00000236221, ENSG00000229353, ENSG00000229341, ENSG00000233323, ENSG00000231608, ENSG00000206258, ENSG00000168477 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033327 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tee MK, Thomson AA, Bristow J, Miller WL (juli 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.
- ^ "UniProt, P22105". Pristupljeno 5. 10. 2021. Zanemaren tekst "languageeng." (pomoć)
- ^ a b "Entrez Gene: tenascin XB".
- ^ Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and Tissue Research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324. S2CID 5889106.
Dopunska literatura[uredi | uredi izvor]
- Goepel C (2008). "Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse". Acta Histochem. 110 (3): 204–9. doi:10.1016/j.acthis.2007.10.014. PMID 18155129.
- Yuan Y, Nymoen DA, Stavnes HT, et al. (2009). "Tenascin-X is a novel diagnostic marker of malignant mesothelioma". Am. J. Surg. Pathol. 33 (11): 1673–82. doi:10.1097/PAS.0b013e3181b6bde3. PMC 2783994. PMID 19738457.
- Egging D, van Vlijmen-Willems I, van Tongeren T, et al. (2007). "Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition". Connect. Tissue Res. 48 (2): 93–8. doi:10.1080/03008200601166160. PMID 17453911. S2CID 34586536.
- Egging DF, van Vlijmen-Willems I, Choi J, et al. (2008). "Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice". Cell Tissue Res. 332 (3): 523–32. doi:10.1007/s00441-008-0591-y. PMC 2386751. PMID 18335242.
- Kato A, Endo T, Abiko S, et al. (2008). "Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions". Exp. Cell Res. 314 (14): 2661–73. doi:10.1016/j.yexcr.2008.05.019. PMID 18588874.
- Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". American Journal of Medical Genetics. 139C (1): 24–30. doi:10.1002/ajmg.c.30071. PMID 16278880. S2CID 23825221.
- Fellay J, Ge D, Shianna KV, et al. (2009). McCarthy MI (ured.). "Common genetic variation and the control of HIV-1 in humans". PLOS Genet. 5 (12): e1000791. doi:10.1371/journal.pgen.1000791. PMC 2791220. PMID 20041166.
- Kamatani Y, Matsuda K, Ohishi T, et al. (2008). "Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population". J. Hum. Genet. 53 (1): 64–73. doi:10.1007/s10038-007-0219-1. PMID 18058064.
- Valdes AM, Thomson G (2009). "Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1". Diabetes Obes Metab. 11. Suppl 1: 46–52. doi:10.1111/j.1463-1326.2008.01002.x. PMC 2755069. PMID 19143814.
- Yu CY (1998). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. S2CID 25061446.
- Endo T, Ariga H, Matsumoto K (2009). "Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5". Mol. Cell. Biochem. 320 (1–2): 53–66. doi:10.1007/s11010-008-9898-y. PMID 18679583. S2CID 23394214.
- Sovio U, Bennett AJ, Millwood IY, et al. (2009). Gibson G (ured.). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genet. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
- Araújo VC, Furuse C, Cury PR, et al. (2008). "Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Appl. Immunohistochem. Mol. Morphol. 16 (1): 48–53. doi:10.1097/PAI.0b013e31802eff1c. PMID 18091320. S2CID 23304572.
- Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951. S2CID 3005450.
- Barcellos LF, May SL, Ramsay PP, et al. (2009). Roopenian DC (ured.). "High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions". PLOS Genet. 5 (10): e1000696. doi:10.1371/journal.pgen.1000696. PMC 2758598. PMID 19851445.
- McKinnon E, Morahan G, Nolan D, et al. (2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach". Diabetes Obes Metab. 11 (Suppl 1): 92–100. doi:10.1111/j.1463-1326.2008.01009.x. PMC 2755510. PMID 19143821.
- Chapuis J, Hot D, Hansmannel F, et al. (2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11): 1004–16. doi:10.1038/mp.2009.10. PMC 2860783. PMID 19204726.
- Vignal C, Bansal AT, Balding DJ, et al. (2009). "Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis Rheum. 60 (1): 53–62. doi:10.1002/art.24138. PMID 19116923.
- Buysschaert ID, Grulois V, Eloy P, et al. (2010). "Genetic evidence for a role of IL33 in nasal polyposis". Allergy. 65 (5): 616–22. doi:10.1111/j.1398-9995.2009.02227.x. PMID 19860791. S2CID 33878118.
- Gudbjartsson DF, Bjornsdottir US, Halapi E, et al. (2009). "Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction". Nat. Genet. 41 (3): 342–7. doi:10.1038/ng.323. PMID 19198610. S2CID 4964308.
Vanjski linkovi[uredi | uredi izvor]
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.