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Timus -specifična serin -proteaza enzim koji je kod ljudi kodiran genom PRSS16 .[ 5] [ 6]
Dužina polipeptidnog lanca je 514 aminokiselina , а molekulska težina 55.049 Da .[ 7]
10 20 30 40 50 MAVWLAQWLG PLLLVSLWGL LAPASLLRRL GEHIQQFQES SAQGLGLSLG PGAAALPKVG WLEQLLDPFN VSDRRSFLQR YWVNDQHWVG QDGPIFLHLG GEGSLGPGSV MRGHPAALAP AWGALVISLE HRFYGLSIPA GGLEMAQLRF LSSRLALADV VSARLALSRL FNISSSSPWI CFGGSYAGSL AAWARLKFPH LIFASVASSA PVRAVLDFSE YNDVVSRSLM STAIGGSLEC RAAVSVAFAE VERRLRSGGA AQAALRTELS ACGPLGRAEN QAELLGALQA LVGGVVQYDG QTGAPLSVRQ LCGLLLGGGG NRSHSTPYCG LRRAVQIVLH SLGQKCLSFS RAETVAQLRS TEPQLSGVGD RQWLYQTCTE FGFYVTCENP RCPFSQLPAL PSQLDLCEQV FGLSALSVAQ AVAQTNSYYG GQTPGANKVL FVNGDTDPWH VLSVTQALGS SESTLLIRTG SHCLDMAPER PSDSPSLRLG RQNIFQQLQT WLKLAKESQI KGEV
Ovaj gen kodira serin-proteazu eksprimiranu isključivo u timusu . Smatra se da ima ulogu u alternativnom putu prezentacije antigena koji koriste epitelne ćelije kore timusa, tokom pozitivne selekcije T-ćelija .
Gen se nalazi u velikoj grupi histonskih gena na hromosomu 6 , u blizini glavnog kompleksa histokompatibilnosti (MHC) klase I. Opisana je druga varijanta transkripta , ali nije utvrđena njena puna dužina.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000112812 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006179 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology . 196 (2): 80–6. doi :10.1006/cimm.1999.1543 . PMID 10527559 . ^ a b "Entrez Gene: PRSS16 protease, serine, 16 (thymus)" .^ "UniProt, Q9NQE7" (jezik: engleski). Pristupljeno 4. 10. 2021 .
Lie BA, Viken MK, Akselsen HE, et al. (2007). "Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease". Hum. Immunol . 68 (7): 592–8. doi :10.1016/j.humimm.2007.03.009 . PMID 17584581 . Luther C, Wienhold W, Oehlmann R, et al. (2005). "Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus" . Genes Immun . 6 (1): 1–7. doi :10.1038/sj.gene.6364142 PMID 15592422 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. doi :10.1038/nature02055 PMID 14574404 . Lie BA, Akselsen HE, Bowlus CL, et al. (2003). "Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases" . Genes Immun . 3 (5): 306–12. doi :10.1038/sj.gene.6363858 PMID 12140752 . Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics . 36 (1): 70–85. doi :10.1006/geno.1996.0427 . PMID 8812418 .
PRSS16 UCSC Genome Browser .
