S Wikipedije, slobodne enciklopedije
Replikacijski inicijator 1 jest protein koji je kod ljudi kodiran genom REPIN1 .[ 5] [ 6]
Dužina polipeptidnog lanca je 567 aminokiselina , а molekulska težina 63.575 Da .[ 7]
10 20 30 40 50 MLERRCRGPL AMGLAQPRLL SGPSQESPQT LGKESRGLRQ QGTSVAQSGA QAPGRAHRCA HCRRHFPGWV ALWLHTRRCQ ARLPLPCPEC GRRFRHAPFL ALHRQVHAAA TPDLGFACHL CGQSFRGWVA LVLHLRAHSA AKRPIACPKC ERRFWRRKQL RAHLRRCHPP APEARPFICG NCGRSFAQWD QLVAHKRVHV AEALEEAAAK ALGPRPRGRP AVTAPRPGGD AVDRPFQCAC CGKRFRHKPN LIAHRRVHTG ERPHQCPECG KRFTNKPYLT SHRRIHTGEK PYPCKECGRR FRHKPNLLSH SKIHKRSEGS AQAAPGPGSP QLPAGPQESA AEPTPAVPLK PAQEPPPGAP PEHPQDPIEA PPSLYSCDDC GRSFRLERFL RAHQRQHTGE RPFTCAECGK NFGKKTHLVA HSRVHSGERP FACEECGRRF SQGSHLAAHR RDHAPDRPFV CPDCGKAFRH KPYLAAHRRI HTGEKPYVCP DCGKAFSQKS NLVSHRRIHT GERPYACPDC DRSFSQKSNL ITHRKSHIRD GAFCCAICGQ TFDDEERLLA HQKKHDV
U studiji funkcije proteina REPIN1 upotrebljeni su i modelni organizmi . Uvjetna linija nokaut-miševa zvana Repin1tm1a(EUCOMM)Wtsi geneirana je na Institutu Wellcome Trust Sanger .[ 8] fenotipskom skriningu [ 9] delecije .[ 10] [ 11] [ 12] [ 13] fenotipizacijom :[ 14]
^ a b c GRCh38: Ensembl release 89: ENSG00000214022 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052751 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Houchens CR, Montigny W, Zeltser L, Dailey L, Gilbert JM, Heintz NH (Jan 2000). "The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region" . Nucleic Acids Research . 28 (2): 570–81. doi :10.1093/nar/28.2.570 . PMC 102514 PMID 10606657 . ^ "Entrez Gene: REPIN1 replication initiator 1" .^ "UniProt, Q9BWE0" (jezik: engleski). Pristupljeno 28. 9. 2021 .^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ a b "International Mouse Phenotyping Consortium" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (Jun 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes" . Cell . 154 (2): 452–64. doi :10.1016/j.cell.2013.06.022 . PMC 3717207 PMID 23870131 . ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium" .[mrtav link
Dailey L, Caddle MS, Heintz N, Heintz NH (Dec 1990). "Purification of RIP60 and RIP100, mammalian proteins with origin-specific DNA-binding and ATP-dependent DNA helicase activities" . Molecular and Cellular Biology . 10 (12): 6225–35. doi :10.1128/mcb.10.12.6225 . PMC 362897 PMID 2174103 . Caddle MS, Dailey L, Heintz NH (Dec 1990). "RIP60, a mammalian origin-binding protein, enhances DNA bending near the dihydrofolate reductase origin of replication" . Molecular and Cellular Biology . 10 (12): 6236–43. doi :10.1128/mcb.10.12.6236 . PMC 362898 PMID 2247056 . Mastrangelo IA, Held PG, Dailey L, Wall JS, Hough PV, Heintz N, Heintz NH (Aug 1993). "RIP60 dimers and multiples of dimers assemble link structures at an origin of bidirectional replication in the dihydrofolate reductase amplicon of Chinese hamster ovary cells". Journal of Molecular Biology . 232 (3): 766–78. doi :10.1006/jmbi.1993.1430 . PMID 8355269 . Montigny WJ, Houchens CR, Illenye S, Gilbert J, Coonrod E, Chang YC, Heintz NH (maj 2001). "Condensation by DNA looping facilitates transfer of large DNA molecules into mammalian cells" . Nucleic Acids Research . 29 (9): 1982–8. doi :10.1093/nar/29.9.1982 . PMC 37261 PMID 11328883 . Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation" . Nature Biotechnology . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Kim MY, Jeong BC, Lee JH, Kee HJ, Kook H, Kim NS, Kim YH, Kim JK, Ahn KY, Kim KK (Aug 2006). "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells" . Proceedings of the National Academy of Sciences of the United States of America . 103 (35): 13074–9. doi :10.1073/pnas.0601915103 PMC 1551900 PMID 16924111 .
(1) Basic domains
(1.1) Osnovni leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Grupa CPAS Grupa D Grupa E Grupa F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Cinkov prst DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
potporodica 1 potporodica 2 potporodica 3 potporodica 4 potporodica 5 potporodica 6 potporodica 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
