DAK (gen)

DAK (gen)
Identifikatori
Aliasi	TKFC
Vanjski ID-jevi	OMIM: 615844 MGI: 2385084 HomoloGene: 56710 GeneCards: TKFC
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek) Bend 11q12.2 Početak 61,333,220 bp Kraj 61,353,295 bp
Lokacija gena (miš) Hrom. Hromosom 19 (miš) Bend 19|19 A Početak 10,565,155 bp Kraj 10,583,018 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • aktivnost sa transferazom • nucleotide binding • vezivanje iona metala • kinase activity • GO:0001948, GO:0016582 vezivanje za proteine • glycerone kinase activity • catalytic activity • lyase activity • triokinase activity • FAD-AMP lyase (cyclizing) activity • ATP binding Ćelijska komponenta • citosol • Egzosom • jedro Biološki proces • negative regulation of MDA-5 signaling pathway • regulation of innate immune response • Fosforilacija • fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate • carbohydrate phosphorylation • cellular carbohydrate metabolic process • metabolizam • Urođeni imunski sistem • glycerol metabolic process • glycerol catabolic process Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	26007	225913
Ensembl	ENSG00000149476	ENSMUSG00000034371
UniProt	Q3LXA3	Q8VC30
RefSeq (mRNK)	NM_015533 NM_001351976 NM_001351977 NM_001351978 NM_001351979 NM_001351980	NM_145496
RefSeq (bjelančevina)	NP_056348 NP_001338905 NP_001338906 NP_001338907 NP_001338908 NP_001338909	NP_663471
Lokacija (UCSC)	Chr 11: 61.33 – 61.35 Mb	Chr 19: 10.57 – 10.58 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Triokinaza/FMN ciklaza je enzim koji je kod ljudi kodiran genom DAK.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 575 aminokiselina, a molekulska težina 58.947 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MTSKKLVNSV		AGCADDALAG		LVACNPNLQL		LQGHRVALRS		DLDSLKGRVA
LLSGGGSGHE		PAHAGFIGKG		MLTGVIAGAV		FTSPAVGSIL		AAIRAVAQAG
TVGTLLIVKN		YTGDRLNFGL		AREQARAEGI		PVEMVVIGDD		SAFTVLKKAG
RRGLCGTVLI		HKVAGALAEA		GVGLEEIAKQ		VNVVAKAMGT		LGVSLSSCSV
PGSKPTFELS		ADEVELGLGI		HGEAGVRRIK		MATADEIVKL		MLDHMTNTTN
ASHVPVQPGS		SVVMMVNNLG		GLSFLELGII		ADATVRSLEG		RGVKIARALV
GTFMSALEMP		GISLTLLLVD		EPLLKLIDAE		TTAAAWPNVA		AVSITGRKRS
RVAPAEPQEA		PDSTAAGGSA		SKRMALVLER		VCSTLLGLEE		HLNALDRAAG
DGDCGTTHSR		AARAIQEWLK		EGPPPASPAQ		LLSKLSVLLL		EKMGGSSGAL
YGLFLTAAAQ		PLKAKTSLPA		WSAAMDAGLE		AMQKYGKAAP		GDRTMLDSLW
AAGQELQAWK		SPGADLLQVL		TKAVKSAEAA		AEATKNMEAG		AGRASYISSA
RLEQPDPGAV		AAAAILRAIL		EVLQS

Funkcija

Ovaj gen je član porodice dihidroksiaceton-kinaza, koji se po proteinskoj strukturi razlikuju od ostalih kinaza. Proizvod ovog gena fosforilizira dihidroksiaceton, a također katalizira stvaranje riboflavin 4', 5'-fosfata (poznatog i kao ciklični FMN) iz FAD. Identificirano je nekoliko alternativno prerađenih varijanti transkripta, ali je samo za jednu utvrđenu cjelovitu prirodu.

Dopunska literatura

• Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB (juli 2007). "Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11706–11. doi:10.1073/pnas.0700544104. PMC 1913852. PMID 17600090.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (januar 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Cabezas A, Costas MJ, Pinto RM, Couto A, Cameselle JC (decembar 2005). "Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases". Biochemical and Biophysical Research Communications. 338 (4): 1682–9. doi:10.1016/j.bbrc.2005.10.142. PMID 16289032.
• Cheek S, Ginalski K, Zhang H, Grishin NV (2006). "A comprehensive update of the sequence and structure classification of kinases". BMC Structural Biology. 5: 6. doi:10.1186/1472-6807-5-6. PMC 1079889. PMID 15771780.
• Cabezas A, Pinto RM, Fraiz F, Canales J, González-Santiago S, Cameselle JC (novembar 2001). "Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion". Biochemistry. 40 (45): 13710–22. doi:10.1021/bi0157159. PMID 11695920.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (oktobar 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (januar 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.