MOXD1
Protein 1 DBH-olike monooksigenaze, znan i kao monooksigenaza X, jest enzim koji je kod ljudi kodiran genom MOXD1.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 613 aminokiselina, а molekulska težina 69.652 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MCCWPLLLLW | GLLPGTAAGG | SGRTYPHRTL | LDSEGKYWLG | WSQRGSQIAF | ||||
| RLQVRTAGYV | GFGFSPTGAM | ASADIVVGGV | AHGRPYLQDY | FTNANRELKK | ||||
| DAQQDYHLEY | AMENSTHTII | EFTRELHTCD | INDKSITDST | VRVIWAYHHE | ||||
| DAGEAGPKYH | DSNRGTKSLR | LLNPEKTSVL | STALPYFDLV | NQDVPIPNKD | ||||
| TTYWCQMFKI | PVFQEKHHVI | KVEPVIQRGH | ESLVHHILLY | QCSNNFNDSV | ||||
| LESGHECYHP | NMPDAFLTCE | TVIFAWAIGG | EGFSYPPHVG | LSLGTPLDPH | ||||
| YVLLEVHYDN | PTYEEGLIDN | SGLRLFYTMD | IRKYDAGVIE | AGLWVSLFHT | ||||
| IPPGMPEFQS | EGHCTLECLE | EALEAEKPSG | IHVFAVLLHA | HLAGRGIRLR | ||||
| HFRKGKEMKL | LAYDDDFDFN | FQEFQYLKEE | QTILPGDNLI | TECRYNTKDR | ||||
| AEMTWGGLST | RSEMCLSYLL | YYPRINLTRC | ASIPDIMEQL | QFIGVKEIYR | ||||
| PVTTWPFIIK | SPKQYKNLSF | MDAMNKFKWT | KKEGLSFNKL | VLSLPVNVRC | ||||
| SKTDNAEWSI | QGMTALPPDI | ERPYKAEPLV | CGTSSSSSLH | RDFSINLLVC | ||||
| LLLLSCTLST | KSL |
Funkcija[uredi | uredi izvor]
DBH-oliki protein 1 održava mnoge strukturna obilježja dopamin beta-monooksigenaza DBH.[8] Budući da je peptidilglicin alfa-hidroksilirajuća monooksigenaza (PHM; EC 1.14.17.3) homologna dopamin beta-monooksigenazi (DBM; EC 1.14.17.1)[9] ovo se odnosi na strukturnu osnovu za novu porodicu bakarni tip II, značajno specifičnu za monooksigenaze ovisne od askorbata.[9] na osnovu odgovarajućeg mišjeg homologa.[6] Put sinteze kateholamina je moguće vezivanje kateholamina za metabolički bakar.[10] enzimski domen, svojstvo nalik neuronskom koje kodira MOX bez signalne sekvence [metabolizam|[metabolizma]] enzima koji rješava monooksigenazni X hemijski put [10] nepoznatog supstrata,[6] egzogeni MOX se ne izlučuje i lokalizira se u cijelom endoplazmatskom retikulumu,[11] i u endokrinim i/ili u neendokrinim ćelijama.[10]
Klinički značaj[uredi | uredi izvor]
Nedostatak DBH efikasno je liječen L-treo-3,4-dihidroksifenilserinom (DOPS).[12]
Također gledajte[uredi | uredi izvor]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000079931 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020000 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: monooxygenase, DBH-like 1".
- ^ a b c Chambers KJ, Tonkin LA, Chang E, Shelton DN, Linskens MH, Funk WD (septembar 1998). "Identification and cloning of a sequence homologue of dopamine beta-hydroxylase" (PDF). Gene. 218 (1–2): 111–20. doi:10.1016/S0378-1119(98)00344-8. PMID 9751809.
- ^ "UniProt, Q6UVY6" (jezik: engleski). Pristupljeno 9. 10. 2021.
- ^ Prigge ST, Mains RE, Eipper BA, Amzel LM (august 2000). "New insights into copper monooxygenases and peptide amidation: structure, mechanism and function". Cell Mol Life Sci. 57 (8–9): 1236–59. doi:10.1007/PL00000763. ISSN 1420-682X. PMID 11028916. S2CID 12738480.
- ^ a b Southan C, Kruse LI (septembar 1989). "Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain". FEBS Lett. 255 (1): 116–20. doi:10.1016/0014-5793(89)81072-5. PMID 2792366. S2CID 84464131.
- ^ a b c Xin X, Mains RE, Eipper BA (novembar 2004). "Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum". J. Biol. Chem. 279 (46): 48159–67. doi:10.1074/jbc.M407486200. PMID 15337741.
- ^ Greška kod citiranja: Nevaljana oznaka
<ref>; nije naveden tekst za reference s imenompmid15337741| - ^ Vincent S, Robertson D (maj 2002). "The broader view: catecholamine abnormalities". Clin Auton Res. Suppl. 1 (7): 144–9. doi:10.1007/s102860200018. ISSN 0959-9851. PMID 12102462. S2CID 28678929.
Dopunska literatura[uredi | uredi izvor]
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Xin X, Mains RE, Eipper BA (2004). "Monooxygenase X, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum". J. Biol. Chem. 279 (46): 48159–67. doi:10.1074/jbc.M407486200. PMID 15337741.
- Bon S, Lamouroux A, Vigny A, Massoulié J, Mallet J, Henry JP (oktobar 1991). "Amphiphilic and nonamphiphilic forms of bovine and human dopamine beta-hydroxylase". J. Neurochem. 57 (4): 1100–11. doi:10.1111/j.1471-4159.1991.tb08267.x. ISSN 0022-3042. PMID 1654385. S2CID 85087782.
