CCL3

CCL3
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifikatori
Aliasi	CCL3
Vanjski ID-jevi	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	36,090,169 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein kinase activity; • cytokine activity; • CCR5 chemokine receptor binding; • chemokine activity; • CCR1 chemokine receptor binding; • kinase activity; • phospholipase activator activity; • calcium-dependent protein kinase C activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje identičnih proteina; • chemoattractant activity; • CCR chemokine receptor binding;
Ćelijska komponenta	• citoplazma; • citosol; • intracellular anatomical structure; • extracellular region; • Vanćelijsko;
Biološki proces	• G protein-coupled receptor signaling pathway; • signaling; • negative regulation of bone mineralization; • positive regulation of protein kinase B signaling; • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • response to cholesterol; • positive regulation of calcium-mediated signaling; • regulation of sensory perception of pain; • protein kinase B signaling; • monocyte chemotaxis; • negative regulation of osteoclast differentiation; • astrocyte cell migration; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • chemokine-mediated signaling pathway; • T cell chemotaxis; • cell-cell signaling; • cellular response to tumor necrosis factor; • eosinophil chemotaxis; • GO:1904579 cellular response to organic cyclic compound; • cellular calcium ion homeostasis; • negative regulation of gene expression; • neutrophil chemotaxis; • cell activation; • MAPK cascade; • Hemotaksija; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • positive regulation of neuron apoptotic process; • positive regulation of calcium ion import; • macrophage chemotaxis; • GO:1901313 positive regulation of gene expression; • cytoskeleton organization; • osteoblast differentiation; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • positive regulation of tumor necrosis factor production; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • inflammatory response; • granulocyte chemotaxis; • response to toxic substance; • eosinophil degranulation; • lipopolysaccharide-mediated signaling pathway; • calcium ion transport; • calcium-mediated signaling; • Egzocitoza; • positive regulation of calcium ion transport; • positive chemotaxis; • positive regulation of inflammatory response; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • regulation of behavior; • positive regulation of microglial cell activation; • positive regulation of microglial cell migration;
	Izvori:Amigo / QuickGO
Ortolozi
	6348
	n/a
	ENSG00000278567; ENSG00000277632; ENSG00000274221
	n/a
	P10147
	n/a
	NM_002983
	n/a
	NP_002974
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 3 (CCL3), znan i kao makrofagni upalni protein 1-alfa (MIP-1-alfa) je protein koji je kod ljudi kodiran genom CCL.^[3]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 92 aminokiseline, a molekulska težina 10.085 Da.^[4].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MQVSTAALAV		LLCTMALCNQ		FSASLAADTP		TACCFSYTSR		QIPQNFIADY
FETSSQCSKP		GVIFLTKRSR		QVCADPSEEW		VQKYVSDLEL		SA

Funkcija[uredi | uredi izvor]

CCL3 je citokin koji pripada porodici CC hemokina koji su uključeni u akutno upalno stanje u regrutovanju i aktivaciji polimorfojedarnih leukocita^[5] vezanjem na receptore CCR1, CCR4 i CCR5.^[3]

Sherry et al. (1988) demonstrirali su dvije proteinske komponente MIP1, koje se nazivaju alfa (CCL3, ovaj protein) i beta (CCL4).^[3]^[6]

CCL3 izaziva monofaznu groznicu brzog početka, čija je magnituda jednaka ili veća od groznice proizvedene bilo s rekombinantnim ljudskim faktorom nekroze tumora ili rekombinantnim ljudskim interleukinom-1. Međutim, za razliku od ova dva endogena pirogena, inhibitor ciklooksigenaza ibuprofen inhibitor ibuprofen ne može inhibirati groznicu izazvanu MIP-1, a CCL3 može učestvovati u upalnim odgovorom koji nije posredovan sintezom prostaglandina i klinički se ne može ablirati ciklooksigenazom.^[7]

Interakcije[uredi | uredi izvor]

Pokazano je da CCL3 komunicira sa CCL4.^[8] Privlači makrofage, monocite i neutrofile.

Također pogledajte[uredi | uredi izvor]

Makrofagni upalni proteini

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
^ "UniProt, P10147". Pristupljeno 26. 6. 2021.
^ Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
^ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
^ Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.
^ Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

Dopunska literatura[uredi | uredi izvor]

Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CCL3 i stranica sa detaljima o genu CCL3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".

[UniProt-4] "UniProt, P10147". Pristupljeno 26. 6. 2021.

[pmid3279154-5] Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.

[pmid3058856-6] Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.

[pmid2646711-7] Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.

[pmid11278300-8] Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

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