CCL4

CCL4L1
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L, 3TN2, 4RAL
Identifikatori
Aliasi	CCL4L1
Vanjski ID-jevi	OMIM: 603782 GeneCards: CCL4L1
Ontologija gena
Molekularna funkcija	• chemokine activity; • cytokine activity; • GO:0001948, GO:0016582 vezivanje za proteine; • CCR chemokine receptor binding; • CCR5 chemokine receptor binding; • CCR1 chemokine receptor binding; • vezivanje identičnih proteina;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• lymphocyte chemotaxis; • chemokine-mediated signaling pathway; • cellular response to tumor necrosis factor; • G protein-coupled receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • Hemotaksija; • inflammatory response; • cellular response to interleukin-1; • monocyte chemotaxis; • neutrophil chemotaxis; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • regulation of signaling receptor activity; • eosinophil chemotaxis; • positive regulation of calcium-mediated signaling; • positive regulation of natural killer cell chemotaxis; • cell-cell signaling; • response to virus; • establishment or maintenance of cell polarity; • Ćelijska adhezija; • response to toxic substance; • GO:0072468 Transdukcija signala; • positive regulation of calcium ion transport; • cytokine-mediated signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	388372
	n/a
	n/a
	n/a
	Q8NHW4; P13236
	n/a
	NM_207007
	n/a
	NP_996890; NP_002975
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Hemokinski (C-C motivni) ligand 4, znan i kao CCL4, je protein koji je kod ljudi kodiran genom CCL4.^[2]

Dužina polipeptidnog lanca je 92 aminokiseline, a molekulska težina 10.212 Da^[3]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin

M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MKLCVTVLSL		LMLVAAFCSP		ALSAPMGSDP		PTACCFSYTA		RKLPRNFVVD
YYETSSLCSQ		PAVVFQTKRS		KQVCADPSES		WVQEYVYDLE		LN

Funkcija[uredi | uredi izvor]

CCL4, poznat i kao makrofagni upalni protein – 1β (MIP-1β) je CC-hemokin sa specifičnošću za CCR5 receptore. To je hemoatraktant za prirodne ćelije ubice, monocite i niz drugih imunskih ćelija.^[4]

CCL4 je glavni HIV-supresivni faktor koga proizvode CD8 + T-ćelije.^[5]

Perforin niskomemorijski CD8+ T-ćelije koje normalno sintetizira MIP-1-beta.^[6]

CCL4 proizvode: neutrofili, monociti, B-ćelije, T-ćelije, fibroblasti, endotelne i epitelne ćelije.^[7]

Pokazalo se da je koncentracija ovog hemokina u obrnutoj vezi sa mikroRNK-125b. Koncentracija CCL4 u tijelu raste s godinama, što može uzrokovati hroničnu upalu i oštećenje jetre.^[7]^[8]

Interakcije[uredi | uredi izvor]

Pokazano je da CCL4 komunicira sa CCL3.^[9]

CCL4 se veže za receptore povezane sa G-proteinima CCR5 i CCR8.^[7]

Također pogledajte[uredi | uredi izvor]

Makrophagni upalni protein

Reference[uredi | uredi izvor]

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (juni 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
^ "UniProt, P13236". Pristupljeno 27. 6. 2021.
^ Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (decembar 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nature Immunology. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. S2CID 7901253.
^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (decembar 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. Bibcode:1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID 8525373. S2CID 84062618.
^ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (juli 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 9283–8. Bibcode:2001PNAS...98.9283K. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920.
^ ^a ^b ^c Morrison MD, Lundquist PG (april 1974). "Labyrinthine morphology and temperature in cryosurgery (guinea pig)". Acta Oto-Laryngologica. 77 (4): 261–73. doi:10.1111/acel.12294. PMC 4364832. PMID 25620312.
^ Morimoto T, Takagi H, Kondo T (januar 1985). "Canine pancreatic allotransplantation with duodenum (pancreaticoduodenal transplantation) using cyclosporin A". Nagoya Journal of Medical Science. 47 (1–2): 57–66. PMID 3887178.
^ Guan E, Wang J, Norcross MA (april 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

Dopunska literatura[uredi | uredi izvor]

Menten P, Wuyts A, Van Damme J (decembar 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (april 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
Conti L, Fantuzzi L, Del Cornò M, Belardelli F, Gessani S (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Joseph AM, Kumar M, Mitra D (januar 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
Zhao RY, Elder RT (mart 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (april 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.
King JE, Eugenin EA, Buckner CM, Berman JW (april 2006). "HIV tat and neurotoxicity". Microbes and Infection. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
Napolitano M, Modi WS, Cevario SJ, Gnarra JR, Seuanez HN, Leonard WJ (septembar 1991). "The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization". The Journal of Biological Chemistry. 266 (26): 17531–6. PMID 1894635.
Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (juni 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.
Baixeras E, Roman-Roman S, Jitsukawa S, Genevee C, Mechiche S, Viegas-Pequignot E, Hercend T, Triebel F (novembar 1990). "Cloning and expression of a lymphocyte activation gene (LAG-1)". Molecular Immunology. 27 (11): 1091–102. doi:10.1016/0161-5890(90)90097-J. PMID 2247088.
Lipes MA, Napolitano M, Jeang KT, Chang NT, Leonard WJ (decembar 1988). "Identification, cloning, and characterization of an immune activation gene". Proceedings of the National Academy of Sciences of the United States of America. 85 (24): 9704–8. Bibcode:1988PNAS...85.9704L. doi:10.1073/pnas.85.24.9704. PMC 282843. PMID 2462251.
Brown KD, Zurawski SM, Mosmann TR, Zurawski G (januar 1989). "A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes". Journal of Immunology. 142 (2): 679–87. PMID 2521353.
Zipfel PF, Balke J, Irving SG, Kelly K, Siebenlist U (mart 1989). "Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors". Journal of Immunology. 142 (5): 1582–90. PMID 2521882.
Chang HC, Reinherz EL (juni 1989). "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes". European Journal of Immunology. 19 (6): 1045–51. doi:10.1002/eji.1830190614. PMID 2568930.
Miller MD, Hata S, De Waal Malefyt R, Krangel MS (novembar 1989). "A novel polypeptide secreted by activated human T lymphocytes". Journal of Immunology. 143 (9): 2907–16. PMID 2809212.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (septembar 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C (decembar 1995). "Molecular characterization of two murine eosinophil beta chemokine receptors". Journal of Immunology. 155 (11): 5299–305. PMID 7594543.
Combadiere C, Ahuja SK, Murphy PM (juli 1995). "Cloning and functional expression of a human eosinophil CC chemokine receptor". The Journal of Biological Chemistry. 270 (28): 16491–4. doi:10.1074/jbc.270.28.16491. PMID 7622448.
Paolini JF, Willard D, Consler T, Luther M, Krangel MS (septembar 1994). "The chemokines IL-8, monocyte chemoattractant protein-1, and I-309 are monomers at physiologically relevant concentrations". Journal of Immunology. 153 (6): 2704–17. PMID 8077676.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CCL4 i stranica sa detaljima o genu CCL4 u UCSC Genome Browseru.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1972563-2] Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (juni 1990). "Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q". Nucleic Acids Research. 18 (11): 3261–70. doi:10.1093/nar/18.11.3261. PMC 330932. PMID 1972563.

[UniProt-3] "UniProt, P13236". Pristupljeno 27. 6. 2021.

[pmid11702067-4] Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (decembar 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nature Immunology. 2 (12): 1126–32. doi:10.1038/ni735. PMID 11702067. S2CID 7901253.

[pmid8525373-5] Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (decembar 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science. 270 (5243): 1811–5. Bibcode:1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID 8525373. S2CID 84062618.

[pmid11470920-6] Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (juli 2001). "Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the beta -chemokine macrophage inflammatory protein-1beta". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 9283–8. Bibcode:2001PNAS...98.9283K. doi:10.1073/pnas.161298998. PMC 55412. PMID 11470920.

[Morrison_1974-7] Morrison MD, Lundquist PG (april 1974). "Labyrinthine morphology and temperature in cryosurgery (guinea pig)". Acta Oto-Laryngologica. 77 (4): 261–73. doi:10.1111/acel.12294. PMC 4364832. PMID 25620312.

[8] Morimoto T, Takagi H, Kondo T (januar 1985). "Canine pancreatic allotransplantation with duodenum (pancreaticoduodenal transplantation) using cyclosporin A". Nagoya Journal of Medical Science. 47 (1–2): 57–66. PMID 3887178.

[pmid11278300-9] Guan E, Wang J, Norcross MA (april 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

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