HDAC1

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HDAC1
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4BKX, 5ICN

Identifikatori
AliasiHDAC1
Vanjski ID-jeviOMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za HDAC1
Genomska lokacija za HDAC1
Bend1p35.2-p35.1Početak32,292,083 bp[1]
Kraj32,333,635 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za HDAC1
Genomska lokacija za HDAC1
Bend4 D2.2|4 63.26 cMPočetak129,516,104 bp[2]
Kraj129,542,713 bp[2]
Obrazac RNK ekspresije
PBB GE HDAC1 201209 at fs.png
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0001106 transcription corepressor activity
histone deacetylase activity
protein N-terminus binding
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
protein deacetylase activity
histone deacetylase binding
GO:0000975 transcription cis-regulatory region binding
NF-kappaB binding
deacetylase activity
GO:0001948 protein binding
nucleosomal DNA binding
enzyme binding
hydrolase activity
core promoter sequence-specific DNA binding
p53 binding
transcription factor binding
RNA polymerase II core promoter sequence-specific DNA binding
DNA binding
chromatin binding
Krueppel-associated box domain binding
E-box binding
promoter-specific chromatin binding
Ćelijska komponenta citoplazma
NuRD complex
citosol
histone deacetylase complex
Sin3 complex
Nukleoplazma
Jedro
Hromatin
heterochromatin
transcription regulator complex
transcription repressor complex
protein-containing complex
neuronal cell body
Sin3-type complex
Biološki proces hair follicle placode formation
epidermal cell differentiation
chromatin remodeling
regulation of transcription, DNA-templated
rhythmic process
negative regulation of androgen receptor signaling pathway
embryonic digit morphogenesis
negative regulation of apoptotic process
blood coagulation
negative regulation of transcription by RNA polymerase II
eyelid development in camera-type eye
circadian regulation of gene expression
negative regulation of gene expression
positive regulation of transcription, DNA-templated
odontogenesis of dentin-containing tooth
protein deacetylation
histone H4 deacetylation
fungiform papilla formation
negative regulation of myotube differentiation
GO:0022415 viral process
histone deacetylation
negative regulation of canonical Wnt signaling pathway
positive regulation of transcription by RNA polymerase II
transcription, DNA-templated
regulation of signal transduction by p53 class mediator
DNA methylation-dependent heterochromatin assembly
beta-catenin-TCF complex assembly
chromatin organization
positive regulation of cell population proliferation
negative regulation of transcription, DNA-templated
histone H3 deacetylation
regulation of megakaryocyte differentiation
regulation of transcription by RNA polymerase II
endoderm development
Jednodnevni biološki ritam
hippocampus development
neuron differentiation
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of oligodendrocyte differentiation
regulation of endopeptidase activity
regulation of amyloid-beta clearance
negative regulation of intrinsic apoptotic signaling pathway
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_004964

NM_008228

RefSeq (bjelančevina)

NP_004955

NP_032254

Lokacija (UCSC)Chr 1: 32.29 – 32.33 MbChr 4: 129.52 – 129.54 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Histon-deacetilaza 1 (HDAC1) jest enzim koji je kod ljudi kodiran genom HDAC1 sa hromosoma 1.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 482 aminokiseline, a molekulska težina Da. 55.103[6]

1020304050
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRK
MEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDC
PVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGF
CYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHK
YGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVME
MFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNM
TNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDD
PDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKE
KDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA

4

Funkcija[uredi | uredi izvor]

Acetilacija i deacetilacija histona, katalizirana kompleksima više podjedinica, ima ključnu ulogu u regulaciji eukariotske ekspresije gena. Protein kodiran ovim genom pripada porodici histon deacetilaza/acuc/alfa i komponenta je kompleksa histon-deacetilaza. Također je u interakciji sa proteinom supresorom tumora retinoblastoma i ovaj kompleks je ključni element u kontroli proliferacije i diferencijacije ćelija. Zajedno s proteinom-2 MTA2 povezanim s metastazama, deacetilira p53 i modulira njegov učinak na rast i ćelijsku apoptozu.[7]

Modelni organizmi[uredi | uredi izvor]

Fenotip Hdac1 nokaut-miševa
Svojstvo Fenotip
Vijabilnost homozigot Nenormalan
Studija recesivne letalnosti Nenormalan
Plodnost Normalan
Tjelesna težina Normalan
Anksioznost otvorenog polja Normalan
Neurološka procjena Normalan
Snaga stiska Normalan
Test vruće ploče Normalan
Dismorfologija Normalan
Indirektna kalorimetrija Normalan
Test tolerancije glukoze Normalan
Slušni odgovor moždanog stabla Normalan
DEXA Normalan
Radiografija Normalan
Tjelesna temperatura Normalan
Morfologija oka Normalan
Klinička hemija Normalan
Hematologija Normalan
Limfociti periferne krvi Normalan
Mikronukleus test Normalan
Težina srca Normalan
Histopatologija mozga Normalan
Histopatologija oka Normalan
Salmonella infekcija Normalan[8]
Citrobacter infekcija Normalan[9]
Svi testovi i analize prema[10][11]

U proučavanju funkcije HDAC1 korišteni su modelni organizmi. Uvjetna linija nokaut-miševa, zvana Hdac1tm1a(EUCOMM)Wtsi[12][13] gwnwrirana je kao dio programa Međunarodnog konzorcija za nokaut-miševe — visokoprolpusnog projekta mutageneze za generiranje i distribuciju modela životzinjskih bolesti zainteresiranim naučnicima — na Institutu Wellcome Trust Sanger.[14][15][16] Mužjaci i ženke podvrgnute su standardiziranom fenotipskom pregledu kako bi se utvrdili efekti delecija.[10][17] Obavljeno je 25 testova i prijavljena su dva nenormalna fenotipa. Tokom gestacije identifikovan je smanjen broj homozigotnih mutantnih embriona, a nijedan nije preživio do odbijanja. Preostali testovi su obavljeni na heterozigot nimmutantnim odraslim miševima i kod ovih životinja nisu uočene značajne abnormalnosti.[10]

Interakcije[uredi | uredi izvor]

Pokazalo se da HDAC1 interraguje sa:

Također pogledajte[uredi | uredi izvor]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116478 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028800 - Ensembl, maj 2017
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  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. ^ "UniProt, Q13547" (jezik: eng.). Pristupljeno 2021-11-28. CS1 održavanje: nepreporučeni parametar (link) CS1 održavanje: nepoznati jezik (link)
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