Kortikotropinu slični intermedijarni peptid

Općenito
Druga imena	; IUPAC ime: L-arginil-L-prolil-L-valil-L-lizil-L-valil-L-tirozil-L-prolil-L-asparaginil-L-glicil-L-alanil-L-α-glutamil-L-α-aspartil-L-α-glutamil-L-seril-L-alanil-L-α-glutamil-L-alanil-L-fenilalanil-L-prolil-L-leucil-L-α-glutamil-L-fenilalanin
Molekularna formula	C112H165N27O36
CAS registarski broj	53917-42-3
Osobine1
Molarna masa	2465,668 g/mol
	1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima.

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Kortikotropinoliki intermedijarni peptid
Kortikotropinoliki intermedijarni peptid
Identifikatori
Simbol	POMC
NCBI gen	5443
HGNC	9201
OMIM	176830
RefSeq	NM_000939
UniProt	P01189
Ostali podaci
Lokus	Hrom. 2 p23
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

Kod čovjeka, genski lokus POMC je na kratkom (p) kraku hromosomu 2: pozicija 2p.23

Kortikotropinoliki intermedijarni peptid (CLIP), poznat i kao fragment adrenokortikotropnog hormona 18-39 [ACTH (18-39 )], je koji se prirodno pojavljuje kao endogeni neuropeptid sa dokosapeptidnom strukturom i sekvencom aminokiselina: Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod cijepanja veza u proteolizi fadenokortikotropnog hormona (ACTH),^[1]^[2] što je zauzvrat produkt cijepanja proopiomelanokortina (POMC).^[3] Njegova fiziološka uloga je istraživana u različitim tkivima,^[4]^[5] posebno u centralnom nervnom sistemu.^[6]^[7]^[8]^[9]^[10]

Reference[uredi | uredi izvor]

^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. PMID 227883. Arhivirano s originala, 15. 9. 2019. Pristupljeno 27. 8. 2020.
^ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. str. 78. ISBN 978-0-8493-8852-1. Pristupljeno 25 November 2011. CS1 održavanje: nepreporučeni parametar (link)
^ Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. str. 12. ISBN 978-0-12-521441-4. Pristupljeno 25 November 2011. CS1 održavanje: nepreporučeni parametar (link)
^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.
^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784.
^ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. str. 136. ISBN 978-0-8493-4822-8. Pristupljeno 25 November 2011. CS1 održavanje: nepreporučeni parametar (link)
^ Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927.
^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203.
^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852.
^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304.

Vanjski linkovi[uredi | uredi izvor]

Corticotropin-Like Intermediate Lobe Peptide na US National Library of Medicine Medical Subject Headings (MeSH)

Commons ima datoteke na temu: Kortikotropinu slični intermedijarni peptid

[pmid227883-1] Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry. 254 (23): 11903–6. PMID 227883. Arhivirano s originala, 15. 9. 2019. Pristupljeno 27. 8. 2020.

[Fricker1991-2] Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. str. 78. ISBN 978-0-8493-8852-1. Pristupljeno 25 November 2011. CS1 održavanje: nepreporučeni parametar (link)

[NormanLitwack1997-3] Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. str. 12. ISBN 978-0-12-521441-4. Pristupljeno 25 November 2011. CS1 održavanje: nepreporučeni parametar (link)

[pmid6209301-4] Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation. 74 (5): 1886–9. doi:10.1172/JCI111608. PMC 425369. PMID 6209301.

[pmid1849784-5] Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin. 26 (1): 99–111. doi:10.1016/0361-9230(91)90194-O. PMID 1849784.

[InouéInoué1989-6] Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. str. 136. ISBN 978-0-8493-4822-8. Pristupljeno 25 November 2011. CS1 održavanje: nepreporučeni parametar (link)

[pmid1981927-7] Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides. 15 (2): 61–74. doi:10.1016/0143-4179(90)90042-w. PMID 1981927.

[pmid1964203-8] Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides. 15 (2): 75–88. doi:10.1016/0143-4179(90)90043-x. PMID 1964203.

[pmid19529852-9] Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine. 147 (3): 319–22. doi:10.1007/s10517-009-0499-x. PMID 19529852.

[pmid8134304-10] Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides. 14 (6): 1221–4. doi:10.1016/0196-9781(93)90179-K. PMID 8134304.

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