Kortikotropin-oslobađajući hormon

CRH
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3EHU, 3EHT, 1GOE
Identifikatori
Aliasi	CRH
Vanjski ID-jevi	OMIM: 122560 MGI: 88496 HomoloGene: 599 GeneCards: CRH
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	66,178,464 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	19,749,560 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• hormone activity; • corticotropin-releasing hormone receptor 1 binding; • corticotropin-releasing hormone receptor 2 binding; • GO:0001948, GO:0016582 protein binding; • neuropeptide hormone activity; • signaling receptor binding; • corticotropin-releasing hormone activity;
Ćelijska komponenta	• citoplazma; • perikaryon; • varicosity; • extracellular region; • neuronal cell body; • Vanćelijsko;
Biološki proces	• response to cocaine; • response to immobilization stress; • positive regulation of cortisol secretion; • steroid metabolic process; • positive regulation of protein phosphorylation; • negative regulation of luteinizing hormone secretion; • positive regulation of cell death; • associative learning; • ion homeostasis; • lung development; • diterpenoid metabolic process; • response to corticosterone; • female pregnancy; • negative regulation of norepinephrine secretion; • adrenal gland development; • synaptic transmission, dopaminergic; • negative regulation of cell death; • negative regulation of gene expression; • cellular response to dexamethasone stimulus; • positive regulation of corticosterone secretion; • response to estrogen; • locomotory exploration behavior; • regulation of NMDA receptor activity; • regulation of serotonin secretion; • positive regulation of calcium ion import; • glucocorticoid biosynthetic process; • GO:1901313 positive regulation of gene expression; • positive regulation of digestive system process; • rođenje; • response to pain; • positive regulation of circadian sleep/wake cycle, wakefulness; • positive regulation of cell population proliferation; • hypothalamus development; • learning or memory; • hormone-mediated apoptotic signaling pathway; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • response to ethanol; • inflammatory response; • negative regulation of circadian sleep/wake cycle, REM sleep; • response to ether; • positive regulation of behavioral fear response; • GO:0072468 Transdukcija signala; • cellular response to cocaine; • long-term potentiation; • chemical synaptic transmission; • negative regulation of epinephrine secretion; • negative regulation of glucagon secretion; • G protein-coupled receptor signaling pathway; • negative regulation of systemic arterial blood pressure; • positive regulation of cAMP-mediated signaling; • positive regulation of corticotropin secretion;
	Izvori:Amigo / QuickGO
Ortolozi
	1392
	12918
	ENSG00000147571
	ENSMUSG00000049796
	P06850
	Q8CIT0
	NM_000756
	NM_205769
	NP_000747
	NP_991338
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kortikotropin-oslobađajući hormon (CRH) je adrenokortikotropni hormon, koji se također naziva i kortikoliberin ili kortikotropin-oslobađađajući faktor (CRF) , peptid od 41 aminokiseline koga iluče neuroni u prednjem dijelu paraventrikulskog jezgra hipotalamusa i placente.^[5] Hormon stimulira kortikotropne ćelije adenohipofze i inducira oslobađanje adrenokortikotropnog hormona,^[6] što zauzvrat uzrokuje povećanje lučenja proizvoda nadbubrežne žlijezde, kortizola.^[7]

Sintetizira se iz prekursora od 196 aminokiselina , u plazmi ima poluživot od šezdeset minuta i molarnu masu 5000 g /mol. Njegovi sekretorni neuroni nalaze se također u moždanoj kori, limbnom sistemu i kičmenoj moždini. Smatra se da takve lokacije predstavljaju neuronske učinke nastale kao odgovor na stres, poput oslobađanja adrenalina i noradrenalina, tahikardije, hiperglikemije, hipertenzije, između .zlučuje ga hipofiza, a djeluje na kortikotropne ćelije i aktivira sistem adenil-ciklaza koji izaziva povećanje sinteze kortikotropina. Antidiuretski hormon i angiotenzin II, putem ovog oslobađajućeg hormona, pojačavaju i lučenje adrenokortikotropnog hormona. Također posredovanjem CRH, oksitocin inhibira lučenje. Inhibicijski učinak glukokortikoide regulira lučenje kortikoliberina, a regulira ga i uzlazni nerv, koji se nalazi u paraventrikulskom jezgru.

U posljednjoj fazi trudnoće i tokom porođaja, nivo ovog peptida raste, što također povećava aktivnost simpatičkog nervnog sistema, promovirajući na taj način izlučivanje kateholamina, a čini se da je to relevantno u energetskoj ravnoteži. Opisan je i protein koji veže kortikoliberine (CRHBP), specifične za CHR.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147571 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049796 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ulices Córdoba Saucedo, José Eduardo Navarro Zarza, Edgar Gerardo Durán Pérez, Juan Antonio Peralta Calcaneo, Elvira Graciela, Alexanderson Rosas (2006): Neurohormonas hipotalámicas: acciones biológicas y aplicaciones clínicas. Medicina Interna de México, vol.22 No 6: 514-524 |url=https://www.medigraphic.com/pdfs/medintmex/mim-2006/mim066h.pdf |access-date= September 5, 2019}}
^ Valero Politi J. (1998). X. Fuentes Arderiu, M. J. Castiñeiras Lacambra & J. M. Queraltó Compañó (ured.). Bioquímica clínica y patología molecular. II (Second izd.). Barcelona: Editorial Reverté. str. 61. Alteraciones hipotalámicas e hipofisarias. ISBN 84-291-1855-1.
^ Melchitzky Darlene S. Austin, Mark C.. Lewis David A. (2006): Treatise on psychopharmacology | url = https: / /books.google.com/books?id=KuiShi0cj98C&pg=PA89 Alan F. Schatzberg and Charles B. Nemeroff |publisher = Masson | location = Barcelona, ISBN 978-84-458-1426-0, chapter = 3. Chemical neuroanatomy of the primate brain: 89.

Vanjski linkovi[uredi | uredi izvor]

Commons ima datoteke na temu: Kortikotropin-oslobađajući hormon

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147571 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049796 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ulices Córdoba Saucedo, José Eduardo Navarro Zarza, Edgar Gerardo Durán Pérez, Juan Antonio Peralta Calcaneo, Elvira Graciela, Alexanderson Rosas (2006): Neurohormonas hipotalámicas: acciones biológicas y aplicaciones clínicas. Medicina Interna de México, vol.22 No 6: 514-524 |url=https://www.medigraphic.com/pdfs/medintmex/mim-2006/mim066h.pdf |access-date= September 5, 2019}}

[Valero-6] Valero Politi J. (1998). X. Fuentes Arderiu, M. J. Castiñeiras Lacambra & J. M. Queraltó Compañó (ured.). Bioquímica clínica y patología molecular. II (Second izd.). Barcelona: Editorial Reverté. str. 61. Alteraciones hipotalámicas e hipofisarias. ISBN 84-291-1855-1.

[7] Melchitzky Darlene S. Austin, Mark C.. Lewis David A. (2006): Treatise on psychopharmacology | url = https: / /books.google.com/books?id=KuiShi0cj98C&pg=PA89 Alan F. Schatzberg and Charles B. Nemeroff |publisher = Masson | location = Barcelona, ISBN 978-84-458-1426-0, chapter = 3. Chemical neuroanatomy of the primate brain: 89.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

p r u Neurotransmiteri
Aminokiselinski–izvedeni	Glavni nadražajni/inhibitorni sistemi: Glutamat sistem: Agmatin Aspartat Cikloserin Glutamat Glutation Glicin GSNO GSSG Kinurenska kiselina NAA NAAG Prolin Serin; GABA sistem: GABA GABOB GHB; Glicinski sistem: α-Alanin β-Alanin Glicin Hipotaurin Prolin Sarkozin Serin Taurin; GHB sistem: GHB T-HCA (GHC) Biogeni amini: Monoamini: 6-OHM Dopamin Epinefrin (adrenalin) Melatonin NAS (normelatonin) Norepinefrin (noradrenalin) Serotonin (5-HT); Trag amini: 3-Jodotironamin N-Metilfenetilamin N-Metiltriptamin m-Oktopamin p-Oktopamin Feniletanolamin Fenetilamin Sinefrin Triptamin m-Tiramin p-Tiramin; Ostali: Histamin Neuropeptidi: Neuropeptid
Lipidno–izvedeni	Endokanabinoidi: 2-AG 2-AGE (noladin eter) 2-ALPI 2-OG AA-5-HT Anandamid (AEA) DEA LPI NADA NAGly S-NG OEA Oleamid PEA RVD-Hpα SEA Virodhamin (O-AEA) Neurosteroidi: Steroidni hormoni
Nukleobazno–izvedeni	Nukleozidi: Adenozinski sistem: Adenozin ADP AMP ATP
Vitaminski–izvedeni	Holinergični sistem: Acetilholin
Ostali – razni	Gasotransmiteri: Ugljik-monoksid (CO) Vodik-sulfid (H₂S) Dušik-oksid (NO); Kandidati: Acetaldehid Amonijak (NH₃) Karbonil-sulfid (COS) Dušik-oksid (N₂O) Sumpor-dioksid (SO₂)