Timopoetin

TMPO
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1GJJ, 1H9F, 1H9E
Identifikatori
Aliasi	TMPO
Vanjski ID-jevi	OMIM: 188380 MGI: 106920 HomoloGene: 31144 GeneCards: TMPO
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	98,550,351 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	91,017,177 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • lamin binding; • cadherin binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• Hromatin; • nuclear envelope; • jedro; • hromosom; • citoplazma; • integral component of membrane; • nuclear inner membrane; • Jedarna membrana; • membrana;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	7112
	21917
	ENSG00000120802
	ENSMUSG00000019961
	P42166; P42167
	Q61029; Q61033
	NM_001032283; NM_001032284; NM_001307975; NM_003276
NM_001080129; NM_001080130; NM_001080131; NM_001080132; NM_001080134;
	NM_011605; NM_001283048
NP_001027454; NP_001027455; NP_001294904; NP_003267; NP_001027454.1;
	NP_001027455.1; NP_001294904.1; NP_001027454.1
NP_001073598; NP_001073599; NP_001073600; NP_001073601; NP_001269977;
	NP_035735; NP_035735.2
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Timopoetin je protein uključen u indukciju CD90 u timusu. Gen timopoetina (TMPO) kodira tri alternativno prerađene iRNK koje kodiraju proteine od 75 kDa (alfa), 51 kDa (beta) i 39 kDa (gama) koji se sveprisutno ispoljavaju u svim ćelijama. Ljudski gen TMPO nalazi se na hromosomskoj poziciji 12q22 i sastoji se od osam egzona.

Gen TMPO, kod ljudi kodira polipeptid 2 povezan sa laminom (LAP2), izoforme beta/ gama.^[5]^[6] LAP2 je protein unutrašnje jedarne membrane (IN).^[7]

TMPO alfa prisutan je difuzno eksprimiran u ćelijskoom jedru, dok su TMPO beta i gama lokalizirani u jedarnoj membrani. TMPO beta je ljudski homolog mišjeg proteina LAP2. LAP2 igra ulogu u regulaciji jedarne arhitekture vezanjem lamina B1 i hromosome. Ova interakcija je regulirana fosforilacijom tokom mitoze. S obzirom na jedarnu lokalizaciju tri izoforme TMPO, malo je vjerojatno da ovi proteini imaju bilo kakvu ulogu u indukciji CD90.

U timusu nastaje nekoliko tvari s hormonskim djelovanjem, od kojih su poznatiji timozini i timopoetin, ali njihova funkcija još nije posve razjašnjena.Misli se da te tvari vjerojatno reguliraju mnogobrojne fiziološke procese, kao što su diferencijacija timocita, regulacija funkcije limfocita u perifernim limfnim organima, djelovanje na nervni i endokrini sistem, obnavljanje oštećenih krvnih sudova.

Interakcije[uredi | uredi izvor]

Pokazano je da timopoetin međureagira sa Brijerom za faktor integracije 1,^[8] AKAP8L,^[9]^[10] LMNB1^[11]^[12] and LMNA.^[13]^[14]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120802 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019961 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (Jul 1994). "Three distinct human thymopoietins are derived from alternatively spliced mRNAs". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6283–7. doi:10.1073/pnas.91.14.6283. PMC 44185. PMID 7517549.
^ "Entrez Gene: TMPO thymopoietin".
^ Holmer L, Worman HJ (Nov 2001). "Inner nuclear membrane proteins: functions and targeting". Cellular and Molecular Life Sciences. 58 (12–13): 1741–7. doi:10.1007/PL00000813. PMID 11766875.
^ Furukawa K (Aug 1999). "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction". Journal of Cell Science. 112 ( Pt 15) (15): 2485–92. PMID 10393804.
^ Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. PMID 11034899.
^ Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639.
^ Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". European Journal of Biochemistry / FEBS. 251 (3): 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046.
^ Foisner R, Gerace L (Jul 1993). "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation". Cell. 73 (7): 1267–79. doi:10.1016/0092-8674(93)90355-T. PMID 8324822.
^ Markiewicz E, Dechat T, Foisner R, Quinlan RA, Hutchison CJ (Dec 2002). "Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein". Molecular Biology of the Cell. 13 (12): 4401–13. doi:10.1091/mbc.E02-07-0450. PMC 138642. PMID 12475961.
^ Dechat T, Korbei B, Vaughan OA, Vlcek S, Hutchison CJ, Foisner R (Oct 2000). "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473–84. PMID 10984438.

Dopunska literatura[uredi | uredi izvor]

Harris CA, Andryuk PJ, Cline SW, Mathew S, Siekierka JJ, Goldstein G (Jul 1995). "Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2". Genomics. 28 (2): 198–205. doi:10.1006/geno.1995.1131. PMID 8530026.
Dechat T, Vlcek S, Foisner R (Apr 2000). "Review: lamina-associated polypeptide 2 isoforms and related proteins in cell cycle-dependent nuclear structure dynamics". Journal of Structural Biology. 129 (2–3): 335–45. doi:10.1006/jsbi.2000.4212. PMID 10806084.
Twomey JJ, Goldstein G, Lewis VM, Bealmear PM, Good RA (Jun 1977). "Bioassay determinations of thymopoietin and thymic hormone levels in human plasma". Proceedings of the National Academy of Sciences of the United States of America. 74 (6): 2541–5. doi:10.1073/pnas.74.6.2541. PMC 432209. PMID 302007.
Heavner GA, Audhya T, Goldstein G (Feb 1990). "Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines". Regulatory Peptides. 27 (2): 257–62. doi:10.1016/0167-0115(90)90044-W. PMID 2158125.
Fuccello A, Audhya T, Talle MA, Goldstein G (Jan 1984). "Immunoassay for bovine serum thymopoietin: discrimination from splenin by monoclonal antibodies". Archives of Biochemistry and Biophysics. 228 (1): 292–8. doi:10.1016/0003-9861(84)90070-5. PMID 6364989.
Hara H, Hayashi K, Ohta K, Itoh N, Ohta M (Nov 1994). "A new thymopoietin precursor gene from human thymus". Biochemistry and Molecular Biology International. 34 (5): 927–33. PMID 7703909.
Goldstein G, Schlesinger DH, Audhya T (Jun 1994). "Isolation and complete amino acid sequence of human thymopoietin and splenin". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 6249. doi:10.1073/pnas.91.13.6249. PMC 44176. PMID 8016147.
Harris CA, Andryuk PJ, Cline SW, Mathew S, Siekierka JJ, Goldstein G (Jul 1995). "Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2". Genomics. 28 (2): 198–205. doi:10.1006/geno.1995.1131. PMID 8530026.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Berger R, Theodor L, Shoham J, Gokkel E, Brok-Simoni F, Avraham KB, Copeland NG, Jenkins NA, Rechavi G, Simon AJ (maj 1996). "The characterization and localization of the mouse thymopoietin/lamina-associated polypeptide 2 gene and its alternatively spliced products". Genome Research. 6 (5): 361–70. doi:10.1101/gr.6.5.361. PMID 8743987.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Furukawa K, Fritze CE, Gerace L (Feb 1998). "The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain". The Journal of Biological Chemistry. 273 (7): 4213–9. doi:10.1074/jbc.273.7.4213. PMID 9461618.
Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". European Journal of Biochemistry / FEBS. 251 (3): 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046.
Dechat T, Gotzmann J, Stockinger A, Harris CA, Talle MA, Siekierka JJ, Foisner R (Aug 1998). "Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics". The EMBO Journal. 17 (16): 4887–902. doi:10.1093/emboj/17.16.4887. PMC 1170818. PMID 9707448.
Furukawa K (Aug 1999). "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction". Journal of Cell Science. 112 ( Pt 15) (15): 2485–92. PMID 10393804.
Weber PJ, Eckhard CP, Gonser S, Otto H, Folkers G, Beck-Sickinger AG (Jun 1999). "On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family". Biological Chemistry. 380 (6): 653–60. doi:10.1515/BC.1999.081. PMID 10430029.
Dechat T, Korbei B, Vaughan OA, Vlcek S, Hutchison CJ, Foisner R (Oct 2000). "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473–84. PMID 10984438.
Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. PMID 11034899.

Vanjski linkovi[uredi | uredi izvor]

Thymopoietins na US National Library of Medicine Medical Subject Headings (MeSH)

Commons logo

Commons ima datoteke na temu: Timopoetin

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120802 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019961 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7517549-5] Harris CA, Andryuk PJ, Cline S, Chan HK, Natarajan A, Siekierka JJ, Goldstein G (Jul 1994). "Three distinct human thymopoietins are derived from alternatively spliced mRNAs". Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6283–7. doi:10.1073/pnas.91.14.6283. PMC 44185. PMID 7517549.

[entrez-6] "Entrez Gene: TMPO thymopoietin".

[Worman-7] Holmer L, Worman HJ (Nov 2001). "Inner nuclear membrane proteins: functions and targeting". Cellular and Molecular Life Sciences. 58 (12–13): 1741–7. doi:10.1007/PL00000813. PMID 11766875.

[pmid10393804-8] Furukawa K (Aug 1999). "LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction". Journal of Cell Science. 112 ( Pt 15) (15): 2485–92. PMID 10393804.

[pmid11034899-9] Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P (Nov 2000). "HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics". Journal of Cell Science. 113 Pt 21 (21): 3703–13. PMID 11034899.

[pmid12538639-10] Martins S, Eikvar S, Furukawa K, Collas P (Jan 2003). "HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication". The Journal of Cell Biology. 160 (2): 177–88. doi:10.1083/jcb.200210026. PMC 2172640. PMID 12538639.

[pmid9490046-11] Furukawa K, Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". European Journal of Biochemistry / FEBS. 251 (3): 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. PMID 9490046.

[pmid8324822-12] Foisner R, Gerace L (Jul 1993). "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation". Cell. 73 (7): 1267–79. doi:10.1016/0092-8674(93)90355-T. PMID 8324822.

[pmid12475961-13] Markiewicz E, Dechat T, Foisner R, Quinlan RA, Hutchison CJ (Dec 2002). "Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein". Molecular Biology of the Cell. 13 (12): 4401–13. doi:10.1091/mbc.E02-07-0450. PMC 138642. PMID 12475961.

[pmid10984438-14] Dechat T, Korbei B, Vaughan OA, Vlcek S, Hutchison CJ, Foisner R (Oct 2000). "Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins". Journal of Cell Science. 113 Pt 19 (19): 3473–84. PMID 10984438.

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